@inproceedings{b2c9d0521b6949249a698ee5ffa6908a,
title = "Carbon nanoparticles as a multimodal thermoacoustic and photoacoustic contrast agent",
abstract = "We demonstrated the potential of carbon nanoparticles (CNPs) as exogenous contrast agents for both thermoacoustic (TA) tomography (TAT) and photoacoustic (PA) tomography (PAT). In comparison to deionized water, the CNPs provided a four times stronger signal in TAT at 3 GHz. In comparison to blood, The CNPs provided a much stronger signal in PAT over a broad wavelength range of 450-850 nm. Specifically, the maximum signal enhancement in PAT was 9.4 times stronger in the near-infrared window of 635-670 nm. In vivo blood-vessel PA imaging was performed non-invasively on a mouse femoral area. The images, captured after the tail vein injection of CNPs, show a gradual enhancement of the optical absorption in the vessels by up to 230%. The results indicate that CNPs can be potentially used as contrast agents for TAT and PAT to monitor the intravascular or extravascular pathways in clinical applications.",
keywords = "Contrast agents, carbon, nanoparticle, photoacoustic tomography, thermoacoutic tomography",
author = "Xin Cai and Lina Wu and Wenxin Xing and Jun Xia and Liming Nie and Ruiying Zhang and Lanza, {Gregory M.} and Baozhong Shen and Dipanjan Pan and Wang, {Lihong V.}",
year = "2013",
month = mar,
day = "4",
doi = "10.1117/12.2005064",
language = "English",
isbn = "9780819493507",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2013 ; Conference date: 03-02-2013 Through 05-02-2013",
}