Capsid-Incorporation Strategy to Display Antigens for an Alternative Adenoviral Vector Vaccine Approach

Claudia A.J. Van Winkel; Alberto Moreno; David T. Curiel

doi:10.1021/acs.molpharmaceut.8b00591

Capsid-Incorporation Strategy to Display Antigens for an Alternative Adenoviral Vector Vaccine Approach

Claudia A.J. Van Winkel, Alberto Moreno, David T. Curiel

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The adenovirus (Ad) is widely used as a vaccine because of its ability to induce a cellular and humoral immune response. In addition, human clinical trials have validated the safety and efficacy of Ad as a vaccine vector. The traditional approach for employing the adenovirus as vaccine is to configure the antigen genes into the expression cassette of the Ad genome. An alternative method for inducing an immune response is the "capsid-incorporation" strategy. This strategy is based upon the incorporation of proteins or peptides into the capsid proteins. This review will focus on the established uses of this approach as well as highlighting the new developments regarding the capsid-incorporation strategy.

Original language	English
Pages (from-to)	5446-5453
Number of pages	8
Journal	Molecular Pharmaceutics
Volume	15
Issue number	12
DOIs	https://doi.org/10.1021/acs.molpharmaceut.8b00591
State	Published - Dec 3 2018

Keywords

adenovirus
antigen
capsid
capsid incorporation
epitope display
vaccine
virus

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10.1021/acs.molpharmaceut.8b00591

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abstract = "The adenovirus (Ad) is widely used as a vaccine because of its ability to induce a cellular and humoral immune response. In addition, human clinical trials have validated the safety and efficacy of Ad as a vaccine vector. The traditional approach for employing the adenovirus as vaccine is to configure the antigen genes into the expression cassette of the Ad genome. An alternative method for inducing an immune response is the {"}capsid-incorporation{"} strategy. This strategy is based upon the incorporation of proteins or peptides into the capsid proteins. This review will focus on the established uses of this approach as well as highlighting the new developments regarding the capsid-incorporation strategy.",

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AU - Van Winkel, Claudia A.J.

AU - Moreno, Alberto

AU - Curiel, David T.

PY - 2018/12/3

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N2 - The adenovirus (Ad) is widely used as a vaccine because of its ability to induce a cellular and humoral immune response. In addition, human clinical trials have validated the safety and efficacy of Ad as a vaccine vector. The traditional approach for employing the adenovirus as vaccine is to configure the antigen genes into the expression cassette of the Ad genome. An alternative method for inducing an immune response is the "capsid-incorporation" strategy. This strategy is based upon the incorporation of proteins or peptides into the capsid proteins. This review will focus on the established uses of this approach as well as highlighting the new developments regarding the capsid-incorporation strategy.

AB - The adenovirus (Ad) is widely used as a vaccine because of its ability to induce a cellular and humoral immune response. In addition, human clinical trials have validated the safety and efficacy of Ad as a vaccine vector. The traditional approach for employing the adenovirus as vaccine is to configure the antigen genes into the expression cassette of the Ad genome. An alternative method for inducing an immune response is the "capsid-incorporation" strategy. This strategy is based upon the incorporation of proteins or peptides into the capsid proteins. This review will focus on the established uses of this approach as well as highlighting the new developments regarding the capsid-incorporation strategy.

KW - adenovirus

KW - antigen

KW - capsid

KW - capsid incorporation

KW - epitope display

KW - vaccine

KW - virus

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ER -

Capsid-Incorporation Strategy to Display Antigens for an Alternative Adenoviral Vector Vaccine Approach

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