Capsaicin induces apoptosis through ubiquitin-proteasome system dysfunction

Ranjan Maity, Jaiprakash Sharma, Nihar Ranjan Jana

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Capsaicin is an active component of red pepper having an antiproliferative effect in a variety of cancer cells, which recent evidence suggests due to its ability to induce apoptosis. However, the molecular mechanisms through which capsaicin induces apoptosis are not well understood. Here we demonstrate that capsaicin-induced apoptosis is mediated via the inhibition cellular proteasome function. Treatment of capsaicin to mouse neuro 2a cells results in the inhibition of proteasome activity in a dose- and time-dependent manner that seems to correlate with its effect on cell death. The effect of capsaicin on cellular proteasome function is indirect and probably mediated via the generation of oxidative stress. Exposure of capsaicin also causes increased accumulation of ubiquitinated proteins as wells as various target substrates of proteasome like p53 and Bax and p27. Like many other classical proteasome inhibitors, capsaicin also triggers the intrinsic pathway of apoptosis involving mitochondria and induces neurite outgrowth. Our results strongly support for the use of capsaicin as an anticancer drug.

Original languageEnglish
Pages (from-to)933-942
Number of pages10
JournalJournal of cellular biochemistry
Volume109
Issue number5
DOIs
StatePublished - Apr 1 2010

Keywords

  • Apoptosis
  • Bax
  • Capsaicin
  • Cell cycle
  • p27
  • Proteasome

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