TY - JOUR
T1 - Capsaicin
T2 - Current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses
AU - Fattori, Victor
AU - Hohmann, Miriam S.N.
AU - Rossaneis, Ana C.
AU - Pinho-Ribeiro, Felipe A.
AU - Verri, Waldiceu A.
N1 - Publisher Copyright:
© 2016 by the authors.
PY - 2016/7
Y1 - 2016/7
N2 - In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.
AB - In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.
KW - Analgesia
KW - Capsaicinoids
KW - Chili peppers
KW - Desensitization
KW - TRPV1
UR - http://www.scopus.com/inward/record.url?scp=84979220886&partnerID=8YFLogxK
U2 - 10.3390/molecules21070844
DO - 10.3390/molecules21070844
M3 - Review article
C2 - 27367653
AN - SCOPUS:84979220886
SN - 1420-3049
VL - 21
JO - Molecules
JF - Molecules
IS - 7
M1 - 844
ER -