TY - JOUR
T1 - Capsaicin blocks Ca2+ channels in isolated rat trigeminal and hippocampal neurones
AU - Kopanitsa, Maksim V.
AU - Panchenko, Viktor A.
AU - Magura, Elena I.
AU - Lishko, Polina V.
AU - Krishtal, Oleg A.
PY - 1995/11/27
Y1 - 1995/11/27
N2 - Effects of capsaicin, an essential ingredient of hot peppers, on high voltage-activated (HVA) calcium channels were investigated in voltage-clamped and internally perfused acutely dissociated rat trigeminal and hippocampal neurones. In micromolar concentrations capsaicin inhibited the whole HVA Ca2+ current without affecting resting membrane conductance in both types of neurones. IC50 values of 14.5μM and 21.2μM (n = 5) were obtained in sensory and hippocampal neurones, respectively. Capsaicin-induced inhibition became irreversible after prolonged incubation (30s) with the drug. It is concluded that capsaicin is a nonspecific blocker of HVA Ca2+ channels in different types of nerve cells.
AB - Effects of capsaicin, an essential ingredient of hot peppers, on high voltage-activated (HVA) calcium channels were investigated in voltage-clamped and internally perfused acutely dissociated rat trigeminal and hippocampal neurones. In micromolar concentrations capsaicin inhibited the whole HVA Ca2+ current without affecting resting membrane conductance in both types of neurones. IC50 values of 14.5μM and 21.2μM (n = 5) were obtained in sensory and hippocampal neurones, respectively. Capsaicin-induced inhibition became irreversible after prolonged incubation (30s) with the drug. It is concluded that capsaicin is a nonspecific blocker of HVA Ca2+ channels in different types of nerve cells.
KW - Capsaicin: Calcium channel
KW - Freshly isolated neurones
KW - Hippocampus
KW - Rat
KW - Trigeminal
UR - http://www.scopus.com/inward/record.url?scp=0029417019&partnerID=8YFLogxK
U2 - 10.1097/00001756-199511270-00016
DO - 10.1097/00001756-199511270-00016
M3 - Article
C2 - 8747149
AN - SCOPUS:0029417019
SN - 0959-4965
VL - 6
SP - 2338
EP - 2340
JO - NeuroReport
JF - NeuroReport
IS - 17
ER -