Capsaicin blocks Ca2+ channels in isolated rat trigeminal and hippocampal neurones

Maksim V. Kopanitsa, Viktor A. Panchenko, Elena I. Magura, Polina V. Lishko, Oleg A. Krishtal

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20 Scopus citations

Abstract

Effects of capsaicin, an essential ingredient of hot peppers, on high voltage-activated (HVA) calcium channels were investigated in voltage-clamped and internally perfused acutely dissociated rat trigeminal and hippocampal neurones. In micromolar concentrations capsaicin inhibited the whole HVA Ca2+ current without affecting resting membrane conductance in both types of neurones. IC50 values of 14.5μM and 21.2μM (n = 5) were obtained in sensory and hippocampal neurones, respectively. Capsaicin-induced inhibition became irreversible after prolonged incubation (30s) with the drug. It is concluded that capsaicin is a nonspecific blocker of HVA Ca2+ channels in different types of nerve cells.

Original languageEnglish
Pages (from-to)2338-2340
Number of pages3
JournalNeuroReport
Volume6
Issue number17
DOIs
StatePublished - Nov 27 1995

Keywords

  • Capsaicin: Calcium channel
  • Freshly isolated neurones
  • Hippocampus
  • Rat
  • Trigeminal

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