Capping protein: New insights into mechanism and regulation

Martin A. Wear; John A. Cooper

doi:10.1016/j.tibs.2004.06.003

Capping protein: New insights into mechanism and regulation

Martin A. Wear
, John A. Cooper

Research output: Contribution to journal › Review article › peer-review

109 Scopus citations

Abstract

Temporal and spatial control of the actin cytoskeleton are crucial for a range of eukaryotic cellular processes. Capping protein (CP), a ubiquitous highly conserved heterodimer, tightly caps the barbed (fast-growing) end of the actin filament and is an important component in the assembly of various actin structures, including the dynamic branched filament network at the leading edge of motile cells. New research into the molecular mechanism of how CP interacts with the actin filament in vitro and the function of CP in vivo, including discoveries of novel interactions of CP with other proteins, has greatly enhanced our understanding of the role of CP in regulating the actin cytoskeleton.

Original language	English
Pages (from-to)	418-428
Number of pages	11
Journal	Trends in biochemical sciences
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/j.tibs.2004.06.003
State	Published - Aug 2004

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10.1016/j.tibs.2004.06.003

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title = "Capping protein: New insights into mechanism and regulation",

abstract = "Temporal and spatial control of the actin cytoskeleton are crucial for a range of eukaryotic cellular processes. Capping protein (CP), a ubiquitous highly conserved heterodimer, tightly caps the barbed (fast-growing) end of the actin filament and is an important component in the assembly of various actin structures, including the dynamic branched filament network at the leading edge of motile cells. New research into the molecular mechanism of how CP interacts with the actin filament in vitro and the function of CP in vivo, including discoveries of novel interactions of CP with other proteins, has greatly enhanced our understanding of the role of CP in regulating the actin cytoskeleton.",

author = "Wear, \{Martin A.\} and Cooper, \{John A.\}",

note = "Funding Information: We are grateful to members of the Cooper laboratory for helpful discussions and to the reviewers for insightful comments and suggestions. The writing of this review was supported by a grant (GM38542) from the National Institutes of Health to J.A.C.",

year = "2004",

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AU - Wear, Martin A.

AU - Cooper, John A.

N1 - Funding Information: We are grateful to members of the Cooper laboratory for helpful discussions and to the reviewers for insightful comments and suggestions. The writing of this review was supported by a grant (GM38542) from the National Institutes of Health to J.A.C.

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N2 - Temporal and spatial control of the actin cytoskeleton are crucial for a range of eukaryotic cellular processes. Capping protein (CP), a ubiquitous highly conserved heterodimer, tightly caps the barbed (fast-growing) end of the actin filament and is an important component in the assembly of various actin structures, including the dynamic branched filament network at the leading edge of motile cells. New research into the molecular mechanism of how CP interacts with the actin filament in vitro and the function of CP in vivo, including discoveries of novel interactions of CP with other proteins, has greatly enhanced our understanding of the role of CP in regulating the actin cytoskeleton.

AB - Temporal and spatial control of the actin cytoskeleton are crucial for a range of eukaryotic cellular processes. Capping protein (CP), a ubiquitous highly conserved heterodimer, tightly caps the barbed (fast-growing) end of the actin filament and is an important component in the assembly of various actin structures, including the dynamic branched filament network at the leading edge of motile cells. New research into the molecular mechanism of how CP interacts with the actin filament in vitro and the function of CP in vivo, including discoveries of novel interactions of CP with other proteins, has greatly enhanced our understanding of the role of CP in regulating the actin cytoskeleton.

UR - https://www.scopus.com/pages/publications/4043147895

U2 - 10.1016/j.tibs.2004.06.003

DO - 10.1016/j.tibs.2004.06.003

M3 - Review article

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SN - 0968-0004

VL - 29

SP - 418

EP - 428

JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

IS - 8

ER -

Capping protein: New insights into mechanism and regulation

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