Capping protein: New insights into mechanism and regulation

Martin A. Wear, John A. Cooper

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations

Abstract

Temporal and spatial control of the actin cytoskeleton are crucial for a range of eukaryotic cellular processes. Capping protein (CP), a ubiquitous highly conserved heterodimer, tightly caps the barbed (fast-growing) end of the actin filament and is an important component in the assembly of various actin structures, including the dynamic branched filament network at the leading edge of motile cells. New research into the molecular mechanism of how CP interacts with the actin filament in vitro and the function of CP in vivo, including discoveries of novel interactions of CP with other proteins, has greatly enhanced our understanding of the role of CP in regulating the actin cytoskeleton.

Original languageEnglish
Pages (from-to)418-428
Number of pages11
JournalTrends in biochemical sciences
Volume29
Issue number8
DOIs
StatePublished - Aug 2004

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