TY - JOUR
T1 - Capabilities of two- and three-dimensional FDG-PET for detecting small lesions and lymph nodes in the upper torso
T2 - A dynamic phantom study
AU - Raylman, Raymond R.
AU - Kison, Paul V.
AU - Wahl, Richard L.
N1 - Funding Information:
&p.2: knowledgements. We thank Mr. Louis Tluzcek and Dr. Scott Snyder of the University of Michigan PET facility radiochemistry group, and Mr. Bryan Smith and Dr. Samuel Mazza of the West Virginia University PET facility radiochemistry group for the radionuclides utilized in this study. This research was supported by a WVU School of Medicine Research Grant and by a grant from the National Institutes of Health (CA52880).
PY - 1999
Y1 - 1999
N2 - The capabilities and limitations of two-to) and three-dimensional (3D) fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting small tumors and lymph nodes were studied in a phantom modeling the human chest and axilla. Multiple dual-radionuclide phantom studies were performed. Five hollow spheres ranging in diameter from 3 mm to 15 mm were filled with carbon-11 and placed in the axillary and mediastinal regions of an anthropomorphic phantom containing hollow organs filled with 18F to simulate FDG uptake 1 h after injection. Dynamic imaging was performed to acquire PET images with varying target-to-background ratios. Imaging was performed in 2D and 3D acquisition modes, with and without attenuation correction, on a modern PET scanner. Lesion detectability was visually and quantitatively assessed. For objects larger than 9 mm in diameter, target-to-background ratios ranging from ~ 3:1 to ~ 10. 1 were detectable. Objects < 9 mm in diameter required a target-to-background ratio of ≥ 18:1. Target-to-background ratios required for lesion detectability were equivalent for 2D and 3D PET images with and without attenuation correction. In conclusion, 2D and 3D PET with attenuation correction consistently detected 'tumors' ≥ 9 mm. Lesions < 9 mm could be detected if there was high enough tumor uptake No statistically significant differences in lesion detection were found for 2D versus 3D PET, or for attenuation-corrected versus non-attenuation-corrected images.
AB - The capabilities and limitations of two-to) and three-dimensional (3D) fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting small tumors and lymph nodes were studied in a phantom modeling the human chest and axilla. Multiple dual-radionuclide phantom studies were performed. Five hollow spheres ranging in diameter from 3 mm to 15 mm were filled with carbon-11 and placed in the axillary and mediastinal regions of an anthropomorphic phantom containing hollow organs filled with 18F to simulate FDG uptake 1 h after injection. Dynamic imaging was performed to acquire PET images with varying target-to-background ratios. Imaging was performed in 2D and 3D acquisition modes, with and without attenuation correction, on a modern PET scanner. Lesion detectability was visually and quantitatively assessed. For objects larger than 9 mm in diameter, target-to-background ratios ranging from ~ 3:1 to ~ 10. 1 were detectable. Objects < 9 mm in diameter required a target-to-background ratio of ≥ 18:1. Target-to-background ratios required for lesion detectability were equivalent for 2D and 3D PET images with and without attenuation correction. In conclusion, 2D and 3D PET with attenuation correction consistently detected 'tumors' ≥ 9 mm. Lesions < 9 mm could be detected if there was high enough tumor uptake No statistically significant differences in lesion detection were found for 2D versus 3D PET, or for attenuation-corrected versus non-attenuation-corrected images.
KW - Nuclear medicine
KW - Positron emission tomography
KW - Tumor detection
UR - https://www.scopus.com/pages/publications/0033024060
U2 - 10.1007/s002590050357
DO - 10.1007/s002590050357
M3 - Article
C2 - 9933660
AN - SCOPUS:0033024060
SN - 0340-6997
VL - 26
SP - 39
EP - 45
JO - European Journal of Nuclear Medicine
JF - European Journal of Nuclear Medicine
IS - 1
ER -