TY - JOUR
T1 - Cannabis use and cyclical vomiting syndrome
T2 - An open debate
AU - Kilani, Yassine
AU - Aljabiri, Yazan
AU - Arshad, Iqra
AU - Alsakarneh, Saqr
AU - Aldiabat, Mohammad
AU - Castro Puello, Priscila
AU - Vahanyan, Anush
AU - Vikash, Fnu
AU - Kumar, Vikash
AU - Numan, Laith
AU - Thor, Savanna
N1 - Publisher Copyright:
© 2023
PY - 2024/2
Y1 - 2024/2
N2 - Introduction: Cyclical vomiting syndrome (CVS) carries a significant financial burden on the U.S. healthcare system due to the recurrent emergency department visits and inpatient hospitalizations. We aimed to update the literature on the predictors of hospital utilization and readmission among individuals admitted with CVS. Methods: This is a retrospective nationwide study of patients hospitalized with a primary diagnosis of CVS. Using weighted data from the National Inpatient Sample (NIS) and the National Readmission Database (NRD), we conducted a multivariate regression analysis to assess predictors of length of stay (LOS), and 30-day readmission. Results: Primary admissions for CVS totaled 35,055 in the NIS, and 31,240 in the NRD. 2012 patients (6.4%) were readmitted within 30 days. On multivariate regression, cannabis use was associated with reduced LOS (adjusted Mean Difference (aMD) = −0.53 days, 95% CI: −0.68 to −0.38), and 30-day readmissions (adjusted Hazard Ratio (aHR) = 0.63, 95% CI: 0.54–0.73). Discussion: Cannabis use among CVS admissions was associated with reduced LOS and 30-day readmissions; these results could be in fact driven by Cannabis Hyperemesis Syndrome (CHS)-related hospitalizations and the effect of cannabis cessation on decreased symptomatology. ICD-10 coding for CHS should be transitioned to specific codes to improve the differentiation between CVS and CHS-related hospitalizations.
AB - Introduction: Cyclical vomiting syndrome (CVS) carries a significant financial burden on the U.S. healthcare system due to the recurrent emergency department visits and inpatient hospitalizations. We aimed to update the literature on the predictors of hospital utilization and readmission among individuals admitted with CVS. Methods: This is a retrospective nationwide study of patients hospitalized with a primary diagnosis of CVS. Using weighted data from the National Inpatient Sample (NIS) and the National Readmission Database (NRD), we conducted a multivariate regression analysis to assess predictors of length of stay (LOS), and 30-day readmission. Results: Primary admissions for CVS totaled 35,055 in the NIS, and 31,240 in the NRD. 2012 patients (6.4%) were readmitted within 30 days. On multivariate regression, cannabis use was associated with reduced LOS (adjusted Mean Difference (aMD) = −0.53 days, 95% CI: −0.68 to −0.38), and 30-day readmissions (adjusted Hazard Ratio (aHR) = 0.63, 95% CI: 0.54–0.73). Discussion: Cannabis use among CVS admissions was associated with reduced LOS and 30-day readmissions; these results could be in fact driven by Cannabis Hyperemesis Syndrome (CHS)-related hospitalizations and the effect of cannabis cessation on decreased symptomatology. ICD-10 coding for CHS should be transitioned to specific codes to improve the differentiation between CVS and CHS-related hospitalizations.
KW - Cannabinoid
KW - Cannabis
KW - Cannabis hyperemesis syndrome
KW - Cyclical vomiting syndrome
KW - Readmissions
KW - Vomiting
UR - http://www.scopus.com/inward/record.url?scp=85174854782&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2023.10.002
DO - 10.1016/j.dld.2023.10.002
M3 - Article
C2 - 37880016
AN - SCOPUS:85174854782
SN - 1590-8658
VL - 56
SP - 272
EP - 280
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 2
ER -