@article{9375335d061f4325a7723c6be992a38d,
title = "Cannabinoids, cannabis, and cannabis-based medicine for pain management: A protocol for an overview of systematic reviews and a systematic review of randomised controlled trials",
abstract = "Pain is an experience that affects many people worldwide and is associated with higher mortality and lower quality of life. Cannabinoid, cannabis, and cannabis-based medicines (CBMs) are thought to reduce pain, but a proliferation of different products has led to variability in trials, creating a challenge when determining the assessment of efficacy in systematic reviews. We will conduct 2 systematic reviews commissioned by the International Association for the Study of Pain Task Force on the use of cannabinoids, cannabis, and CBMs for pain management: first, an overview review of systematic reviews to summarise the evidence base and second, a systematic review of randomised controlled trials of cannabinoids, cannabis, and CBMs. In these reviews we will determine the harm and benefit of CBM from the current literature and will interpret the findings in light of the quality of evidence and reviews included. We will search online databases and registries in any language for systematic reviews and randomised controlled trials. We will include studies that evaluate any cannabinoid or CBM vs any control for people with acute and chronic pain. Our primary outcomes for both reviews are the number of participants achieving (1) a 30% and (2) 50% reduction in pain intensity, (3) moderate improvement, and (4) substantial improvement. A number of secondary outcome measures will also be included. We will assess risk of bias and quality of evidence. We will analyse data using fixed and random effect models, with separate comparators for cannabis and CBMs. Prospero ID (CRD42019124710; CRD42019124714).",
keywords = "Cannabinoids, Cannabis, Meta-analysis, Overview, Pain, Protocol, Systematic review",
author = "Emma Fisher and Christopher Eccleston and Louisa Degenhardt and Finn, {David P.} and Finnerup, {Nanna B.} and Ian Gilron and Simon Haroutounian and Elliot Krane and Rice, {Andrew S.C.} and Michael Rowbotham and Mark Wallace and {Andrew Moore}, R.",
note = "Funding Information: Cochrane Review Group funding acknowledgement: this project was partly supported by the National Institute for Health Research, via Cochrane Infrastructure funding to the Cochrane Pain, Palliative, and Supportive Care Review Group (PaPaS). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the Systematic Reviews Programme, NIHR, NHS, or the Department of Health. Funding Information: L. Degenhardt reports grants from Indivior and grants from Seqirus, outside the submitted work. D.P. Finn reports grants from Randox Ltd, grants from Alkermes, Inc, and grants from Shionogi Ltd, outside the submitted work. N.B. Finnerup reports personal fees from Gr{\"u}nenthal, personal fees from Teva Pharmaceuticals, personal fees from Astellas, personal fees from Novartis Pharma, personal fees from Mitsubishi Tanabe Pharma, personal fees from Merck, grants from PainCare, IMI2 (Innovative medicines initiative), which is a EU public–private consortium with a grant provided by the EU and the companies involved are: Grunenthal, Bayer, Eli Lilly, Esteve, Novartis, and Teva, outside the submitted work. I. Gilron reports personal fees from Adynxx, personal fees from Biogen, personal fees from Eupraxia, personal fees from Novaremed, personal fees from Teva, nonfinancial support from Canopy Health, nonfinancial support from Toronto Poly Clinic, and nonfinancial support from CannTrust, outside the submitted work. S. Har-outounian reports grants from Pfizer Inc and personal fees from Medoc Ltd, outside the submitted work. A.S.C. Rice is part of the Presidential Task Force of the IASP, during the conduct of the study; personal fees from Imperial College Consultants, other from Spinidex/Novartis, outside the submitted work. In addition, A. Rice has a patent: Rice A.S.C, Vandevoorde S., and Lambert D. M Methods using N-(2propenyl)hexadecanamide and related amides to relieve pain. WO2005/079771 pending, and a patent Okuse K. et al. Methods of treating pain by inhibition of vgf activity EP13702262.0/WO2013 110945 pending. M. Wallace reports personal fees from Insys, outside the submitted work. R.A. Moore reports personal fees from Novartis and personal fees from RB, outside the submitted work. The remaining authors have no conflicts of interest to declare. Publisher Copyright: {\textcopyright} 2019 The Author(s).",
year = "2019",
month = may,
day = "1",
doi = "10.1097/PR9.0000000000000741",
language = "English",
volume = "4",
journal = "Pain Reports",
issn = "2471-2531",
number = "3",
}