Abstract

To describe patients with candiduria and investigate how they are managed in a hospital setting, we reviewed the records of 101 patients hospitalized between January 1, 1990, and December 31, 1990, who had at least one urine culture yielding 104 CFU of yeast or more per milliliter. Virtually all study patients had one or more risk factors for candiduria, including urinary catheters, diabetes mellitus, and antibacterial or immunosuppressive therapy. Specific signs and symptoms referable to the urinary tract were seldom recorded in the medical record. Pyuria was common and did not correlate with the presence of a urinary catheter. Eleven of 105 episodes of candiduria in these 101 patients were accompanied by candidemia during the same hospitalization. All cases of candidemia occurred in patients with obstruction of the upper urinary tract or risk factors for systemic candidiasis. The management of the episodes varied widely; 30 episodes were treated with one or more courses of amphotericin B bladder irrigation. Having 105 CFU of yeast or more per milliliter of urine or yeast isolated from another nonsterile site correlated strongly with treatment with amphotericin B bladder irrigation. Follow-up cultures were performed erratically in treated and untreated patients, making an assessment of the effect of therapy difficult. We conclude that the presence of yeast in urine submitted for culture is a common laboratory finding in hospitalized patients that is erratically managed in an academic medical center. Carefully performed studies of the natural history of candiduria and the effect of antifungal therapy on this condition are needed.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalInfectious Diseases in Clinical Practice
Volume3
Issue number1
StatePublished - 1994

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