Candidate gene analysis of selectin cluster in patients with multiple sclerosis

Chiara Fenoglio, Diego Scalabrini, Laura Piccio, Milena De Riz, Eliana Venturelli, Francesca Cortini, Chiara Villa, Maria Serpente, Becky Parks, John Rinker, Anne H. Cross, Nereo Bresolin, Elio Scarpini, Daniela Galimberti

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Three single nucleotide polymorphisms (SNPs) with a potential impact on the function of selectins (rs6133, rs4987310 and rs5368 substitutions localized in the coding regions of P-sel, L-sel and E-sel, respectively) were analyzed in an Italian population of 165 patients with multiple sclerosis (MS) as compared with 149 controls and in a replication American population of Caucasian descent consisting of 122 patients and 50 controls. No significant differences in either allelic or genotypic frequency in all the SNPs tested were found in the Italian population. A tendency to an increased frequency of the rs6133 T allele was observed in the American population, but applying the Bonferroni correction the significance threshold was not reached. Haploview analysis demonstrated that rs4987310 and rs5368 markers are in strong LD (D′ = 0.97) in both populations. Combining the two SNPs, we found no difference in haplotype distribution in patients compared with controls, either in Italian or in American population. Despite the fact that selectins play a role in the pathogenesis of MS and their encoding genes are located in regions associated with the disease, the selectin gene cluster studied likely does not influence the susceptibility to MS in Caucasians.

Original languageEnglish
Pages (from-to)832-833
Number of pages2
JournalJournal of Neurology
Volume256
Issue number5
DOIs
StatePublished - May 2009

Keywords

  • Multiple sclerosis
  • Polymorphisms
  • Risk factor
  • Selectins

Fingerprint

Dive into the research topics of 'Candidate gene analysis of selectin cluster in patients with multiple sclerosis'. Together they form a unique fingerprint.

Cite this