TY - JOUR
T1 - Cancer to bone
T2 - A fatal attraction
AU - Weilbaecher, Katherine N.
AU - Guise, Theresa A.
AU - McCauley, Laurie K.
N1 - Funding Information:
Dedicated in memory of G. Mundy. The authors would like to thank P. Ross, M. Tomasson, C. Hall, D. Novack, S. Amend, J. Schneider, M. Hurchla and C. Winkeler for feedback on this manuscript. The authors are grateful to K. Pienta (University of Michigan School of Medicine, USA) for providing the gross autopsy specimen from vertebral body involved with prostate cancer, V. Reichert and J. Burkett (Washington University Medical School, St. Louis, USA) for providing the radiological images of bone metastases, R. Aft (Washington University School of Medicine, USA) for providing the photograph of bone marrow disseminated tumour cells, and D. Novack (Washington University School of Medicine) for providing the histological slide from bone metastasis biospy. K.N.W. is supported by the US National Institutes of Health (NIH) (R01-CA52152 and P01-CA100730) and the US Department of Defense (W81XWH-01-1-360). T.A.G. is supported by R01CA69158, R01DK065837, R01DK067333, U01CA143057, V-Foundation and Indiana Economic Development Grant. L.K.M. is supported by the US National Institutes of Health (NIH) (PO1-CA093900, RO1-DK53904), the US Department of Defense (W81XWH-08-1-0037) and Centocor Inc. The authors regret that there are many other important studies that they were unable to include owing to space limitations.
PY - 2011/6
Y1 - 2011/6
N2 - When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and sculpt the bone microenvironment to enhance tumour growth and to promote bone invasion. Understanding the crucial components of the bone microenvironment that influence tumour localization, along with the tumour-derived factors that modulate cellular and protein matrix components of bone to favour tumour expansion and invasion, is central to the pathophysiology of bone metastases. Basic findings of tumourĝ€"bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases.
AB - When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and sculpt the bone microenvironment to enhance tumour growth and to promote bone invasion. Understanding the crucial components of the bone microenvironment that influence tumour localization, along with the tumour-derived factors that modulate cellular and protein matrix components of bone to favour tumour expansion and invasion, is central to the pathophysiology of bone metastases. Basic findings of tumourĝ€"bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases.
UR - https://www.scopus.com/pages/publications/79957484310
U2 - 10.1038/nrc3055
DO - 10.1038/nrc3055
M3 - Review article
C2 - 21593787
AN - SCOPUS:79957484310
SN - 1474-175X
VL - 11
SP - 411
EP - 425
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 6
ER -