Cancer neuroscience: State of the field, emerging directions

Frank Winkler, Humsa S. Venkatesh, Moran Amit, Tracy Batchelor, Ihsan Ekin Demir, Benjamin Deneen, David H. Gutmann, Shawn Hervey-Jumper, Thomas Kuner, Donald Mabbott, Michael Platten, Asya Rolls, Erica K. Sloan, Timothy C. Wang, Wolfgang Wick, Varun Venkataramani, Michelle Monje

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.

Original languageEnglish
Pages (from-to)1689-1707
Number of pages19
JournalCell
Volume186
Issue number8
DOIs
StatePublished - Apr 13 2023

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