Background. Relatively little is known about the factors that impact African Americans' health information seeking, a behavior relevant to cancer disparity. Methods. In this article, we examine African American cancer information seeking using data from Cancer Information Service (CIS) call data (N = 32,834 African American callers). Results. Compared to members of other racial groups, fewer African American callers sought information on prevention and psychosocial support. African American calls were likely to result in information on medical referrals and support services. Conclusions. Increased knowledge of CIS resources relevant to treatment and support may increase African American use of CIS.