Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?

Jack D. Bui, Robert D. Schreiber

Research output: Contribution to journalReview article

212 Scopus citations

Abstract

When immune cells and developing tumor cells localize to a common microenvironment, an assemblage of interactions takes place; this results in either tumor destruction by way of immunosurveillance or tumor outgrowth. These events put a functional imprint onto the emerging tumor repertoire because tumor cells arising in the presence of a fully functional immune system are less immunogenic than those that develop in the absence of immunity (i.e. in RAG2-/- and perforin-/- mice). However, other studies suggest that the immune system can also actively promote formation of certain tumors. These apparent disparate effects of immunity on tumorigenesis provide a unique model for study of the decision-making process that dictates immune function within a tumor.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalCurrent Opinion in Immunology
Volume19
Issue number2
DOIs
StatePublished - Apr 1 2007

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