Cancer Immunosurveillance: Immunoediting

Danielle M. Lussier, Robert D. Schreiber

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Cancer immunoediting is the process wherein immunity not only protects against cancer development but also promotes outgrowth of cancers capable of escaping immune control. As an extrinsic tumor suppressor, immunity exerts selective pressure on developing cancers that can favor outgrowth of cancer cells with reduced immunogenicities. The tumor sculpting action of immunity is a consequence of T cell-dependent immunoselection and/or epigenetic mechanisms that specifically target cancer cells expressing highly immunogenic cancer antigens including tumor-specific mutant neoantigens. Cancer immunoediting thus serves as a conceptual framework that explains the complex interactions that occur between the immune system and developing cancers.

Original languageEnglish
Title of host publicationImmunity to Pathogens and Tumors
PublisherElsevier Inc.
Pages396-405
Number of pages10
Volume4
ISBN (Print)9780080921525
DOIs
StatePublished - Apr 27 2016

Keywords

  • Cancer immunoediting
  • Carcinogen-induced (MCA) tumors
  • Elimination
  • Equilibrium
  • Escape
  • Immune suppression
  • Immunogenic tumors
  • Immunosurveillance
  • Immunotherapies
  • Inhibitory receptors
  • Neoantigen
  • Tumor immune evasion
  • Tumor immune selection

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