Cancer immunoediting is the process wherein immunity not only protects against cancer development but also promotes outgrowth of cancers capable of escaping immune control. As an extrinsic tumor suppressor, immunity exerts selective pressure on developing cancers that can favor outgrowth of cancer cells with reduced immunogenicities. The tumor sculpting action of immunity is a consequence of T cell-dependent immunoselection and/or epigenetic mechanisms that specifically target cancer cells expressing highly immunogenic cancer antigens including tumor-specific mutant neoantigens. Cancer immunoediting thus serves as a conceptual framework that explains the complex interactions that occur between the immune system and developing cancers.

Original languageEnglish
Title of host publicationImmunity to Pathogens and Tumors
PublisherElsevier Inc.
Number of pages10
ISBN (Print)9780080921525
StatePublished - Apr 27 2016


  • Cancer immunoediting
  • Carcinogen-induced (MCA) tumors
  • Elimination
  • Equilibrium
  • Escape
  • Immune suppression
  • Immunogenic tumors
  • Immunosurveillance
  • Immunotherapies
  • Inhibitory receptors
  • Neoantigen
  • Tumor immune evasion
  • Tumor immune selection


Dive into the research topics of 'Cancer Immunosurveillance: Immunoediting'. Together they form a unique fingerprint.

Cite this