Cancer genome sequencing and its implications for personalized cancer vaccines

Lijin Li, Peter Goedegebuure, Elaine R. Mardis, Matthew J.C. Ellis, Xiuli Zhang, John M. Herndon, Timothy P. Fleming, Beatriz M. Carreno, Ted H. Hansen, William E. Gillanders

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

New DNA sequencing platforms have revolutionized human genome sequencing. The dramatic advances in genome sequencing technologies predict that the $1,000 genome will become a reality within the next few years. Applied to cancer, the availability of cancer genome sequences permits real-time decision-making with the potential to affect diagnosis, prognosis, and treatment, and has opened the door towards personalized medicine. A promising strategy is the identification of mutated tumor antigens, and the design of personalized cancer vaccines. Supporting this notion are preliminary analyses of the epitope landscape in breast cancer suggesting that individual tumors express significant numbers of novel antigens to the immune system that can be specifically targeted through cancer vaccines.

Original languageEnglish
Pages (from-to)4191-4211
Number of pages21
JournalCancers
Volume3
Issue number4
DOIs
StatePublished - Dec 2011

Keywords

  • Cancer genome sequencing
  • DNA vaccine
  • Unique tumor antigen

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