TY - JOUR
T1 - Cancer and Cardiovascular Disease
T2 - the Use of Novel Echocardiography Measures to Predict Subsequent Cardiotoxicity in Breast Cancer Treated with Anthracyclines and Trastuzumab
AU - Gulati, Gaurav
AU - Zhang, Kathleen W.
AU - Scherrer-Crosbie, Marielle
AU - Ky, Bonnie
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/12
Y1 - 2014/12
N2 - As the population of breast cancer survivors grows, it has become evident that chemotherapy has significant cardiotoxic side effects. Echocardiography is a noninvasive, cost-effective, and widely available imaging tool that is well positioned to serve as a primary modality for monitoring chemotherapy-induced cardiotoxicity. Although left ventricular ejection fraction is a standard measurement by which to monitor chemotherapy-induced cardiotoxicity, its predictive value in identifying subsequent cardiotoxicity is limited. More sophisticated echocardiography modalities may offer improved sensitivity and specificity for detecting chemotherapy-induced cardiotoxicity. These include tissue Doppler imaging measures, newer techniques based upon two- and three-dimensional strain and torsion analysis, and three-dimensional measures of cardiac size. While these modalities are not all currently part of clinical practice, a body of data supporting their use is steadily building. More research remains to be performed, and noninvasively detecting cancer therapy-induced cardiac dysfunction at the earliest stages is of increasing interest.
AB - As the population of breast cancer survivors grows, it has become evident that chemotherapy has significant cardiotoxic side effects. Echocardiography is a noninvasive, cost-effective, and widely available imaging tool that is well positioned to serve as a primary modality for monitoring chemotherapy-induced cardiotoxicity. Although left ventricular ejection fraction is a standard measurement by which to monitor chemotherapy-induced cardiotoxicity, its predictive value in identifying subsequent cardiotoxicity is limited. More sophisticated echocardiography modalities may offer improved sensitivity and specificity for detecting chemotherapy-induced cardiotoxicity. These include tissue Doppler imaging measures, newer techniques based upon two- and three-dimensional strain and torsion analysis, and three-dimensional measures of cardiac size. While these modalities are not all currently part of clinical practice, a body of data supporting their use is steadily building. More research remains to be performed, and noninvasively detecting cancer therapy-induced cardiac dysfunction at the earliest stages is of increasing interest.
KW - Breast cancer
KW - Cardiotoxicity
KW - Chemotherapy
KW - Echocardiography
KW - Strain
UR - http://www.scopus.com/inward/record.url?scp=84933518637&partnerID=8YFLogxK
U2 - 10.1007/s11897-014-0214-8
DO - 10.1007/s11897-014-0214-8
M3 - Review article
C2 - 25079445
AN - SCOPUS:84933518637
SN - 1546-9530
VL - 11
SP - 366
EP - 373
JO - Current Heart Failure Reports
JF - Current Heart Failure Reports
IS - 4
ER -