Can we apply the TH1-TH2 paradigm to all lymphocytes?

M. Colonna

doi:10.1038/ni1001-899

Can we apply the T_H1-T_H2 paradigm to all lymphocytes?

M. Colonna

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The T_H1-T_H2 paradigm, in which CD4⁺T cells polarize into type 1 or type 2 helper cells, has been extended to other cells types. However, evidence now suggests that NK cells differentiate sequentially from immature type 2 to mature type 1 cells, a pathway that could apply to other lymphocytes.

Original language	English
Pages (from-to)	899-900
Number of pages	2
Journal	Nature immunology
Volume	2
Issue number	10
DOIs	https://doi.org/10.1038/ni1001-899
State	Published - 2001

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10.1038/ni1001-899

Cite this

@article{6b69d13c591c4e6f8ecd7782cafde1a8,

title = "Can we apply the TH1-TH2 paradigm to all lymphocytes?",

abstract = "The TH1-TH2 paradigm, in which CD4+T cells polarize into type 1 or type 2 helper cells, has been extended to other cells types. However, evidence now suggests that NK cells differentiate sequentially from immature type 2 to mature type 1 cells, a pathway that could apply to other lymphocytes.",

author = "M. Colonna",

year = "2001",

doi = "10.1038/ni1001-899",

language = "English",

volume = "2",

pages = "899--900",

journal = "Nature immunology",