The TH1-TH2 paradigm, in which CD4+T cells polarize into type 1 or type 2 helper cells, has been extended to other cells types. However, evidence now suggests that NK cells differentiate sequentially from immature type 2 to mature type 1 cells, a pathway that could apply to other lymphocytes.

Original languageEnglish
Pages (from-to)899-900
Number of pages2
JournalNature immunology
Issue number10
StatePublished - 2001


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