Calpain regulated cell adhesion in EGF-stimulated fibroblast-populated-collagen-lattice contraction

Fred D. Allen, Clara F. Asnes, Philip Chang, Elliot L. Elson, Douglas A. Lauffenburger, Alan Wells

Research output: Contribution to journalConference articlepeer-review

Abstract

Calpain regulated cell adhesion in EGF-stimulated fibroblast-populated-collagen-lattice (FPCL) contraction was investigated. It was shown that fibroblasts capable of EGF/EGFR signaling rapidly generate significant and transient contractile force in response to EGF stimulation. Results also showed that calpain plays an important role in the transfer of that force to the extracellular collagen matrix by modulating cell-matrix adhesion.

Original languageEnglish
Pages (from-to)353-354
Number of pages2
JournalAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Volume50
StatePublished - Dec 1 2001
EventProceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States
Duration: Jun 27 2001Jul 1 2001

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