Calpain regulated cell adhesion in EGF-stimulated fibroblast-populated-collagen-lattice (FPCL) contraction was investigated. It was shown that fibroblasts capable of EGF/EGFR signaling rapidly generate significant and transient contractile force in response to EGF stimulation. Results also showed that calpain plays an important role in the transfer of that force to the extracellular collagen matrix by modulating cell-matrix adhesion.
|Number of pages||2|
|Journal||American Society of Mechanical Engineers, Bioengineering Division (Publication) BED|
|State||Published - Dec 1 2001|
|Event||Proceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States|
Duration: Jun 27 2001 → Jul 1 2001