Calculation of equivalent dose for Auger electron emitting radionuclides distributed in human organs

S. Murty Goddu, Roger W. Howell, Dandamudi V. Rao

Research output: Contribution to journalConference articlepeer-review

16 Scopus citations

Abstract

Radionuclides that emit Auger electrons can be extremely radiotoxic depending on the subcellular distribution of the radiochemical. Despite this, ICRP 60 provides no guidance in the calculation of equivalent dose HT for Auger electrons. The recent report by the American Association of Physicists in Medicine recommends a radiation weighting factor WR of 20 for stochastic effects caused by Auger electrons, along with a method of calculating the equivalent dose that takes into account the subcellular distribution of the radionuclide. In view of these recommendations, it is important to reevaluate equivalent doses from Auger electron emitters. The mean absorbed dose per unit cumulated activity (S-value) from Auger electrons and other radiations is calculated for ninety Auger-electron-emitting radionuclides distributed in human ovaries, testes and liver. Using these S-values, and the formalism given in the recent AAPM report, the dependence of the organ equivalent doses on subcellular distribution of the Auger electron emitters is examined. The results show an increase in the mean equivalent dose for Auger electron emitters when a significant fraction of the organ activity localizes in the DNA.

Original languageEnglish
Pages (from-to)909-916
Number of pages8
JournalActa Oncologica
Volume35
Issue number7
DOIs
StatePublished - 1996
EventProceedings of the 1995 3rd International Symposium on Biophysical Aspects of Auger Processes - Lund, Swed
Duration: Aug 24 1995Aug 25 1995

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