TY - JOUR
T1 - Calcium signaling in axon guidance
AU - Sutherland, Daniel J.
AU - Pujic, Zac
AU - Goodhill, Geoffrey J.
N1 - Funding Information:
We gratefully acknowledge support from National Health and Medical Research Council (NHMRC) Project Grant 1043044, and thank Beth Kita and Rowan Tweedale for providing helpful feedback on earlier versions.
PY - 2014/8
Y1 - 2014/8
N2 - Guidance of axons to their targets in the developing nervous system requires a myriad of downstream signaling molecules to coordinate growth cone movement. One of the most important of these is calcium, and over the past few years many new insights have been gained into the role of calcium in axon guidance. In this review we focus on mechanisms of calcium entry into the growth cone and its downstream effects on both growth cone motility and turning. We particularly highlight the role of calcium concentrations in determining attractive versus repulsive responses to graded guidance cues, and their role in guidance by the morphogen Wnt5a.
AB - Guidance of axons to their targets in the developing nervous system requires a myriad of downstream signaling molecules to coordinate growth cone movement. One of the most important of these is calcium, and over the past few years many new insights have been gained into the role of calcium in axon guidance. In this review we focus on mechanisms of calcium entry into the growth cone and its downstream effects on both growth cone motility and turning. We particularly highlight the role of calcium concentrations in determining attractive versus repulsive responses to graded guidance cues, and their role in guidance by the morphogen Wnt5a.
UR - http://www.scopus.com/inward/record.url?scp=84905085285&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2014.05.008
DO - 10.1016/j.tins.2014.05.008
M3 - Review article
C2 - 24969461
AN - SCOPUS:84905085285
SN - 0166-2236
VL - 37
SP - 424
EP - 432
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 8
ER -