TY - JOUR
T1 - Calcium-Dependent Signaling and Kinases in Apicomplexan Parasites
AU - Billker, Oliver
AU - Lourido, Sebastian
AU - Sibley, L. David
N1 - Funding Information:
All three authors contributed to writing of the text, S.L. and L.D.S. performed the phylogenetic analysis, and S.L. produced the illustrations. This work was partially supported in part by NIH grant AI34036 to L.D.S. S.L. was partially supported by a Morse Berg Predoctoral Graduate Student Fellowship.
PY - 2009/6/18
Y1 - 2009/6/18
N2 - Calcium controls many critical events in the complex life cycles of apicomplexan parasites including protein secretion, motility, and development. Calcium levels are normally tightly regulated and rapid release of calcium into the cytosol activates a family of calcium-dependent protein kinases (CDPKs), which are normally characteristic of plants. CDPKs present in apicomplexans have acquired a number of unique domain structures likely reflecting their diverse functions. Calcium regulation in parasites is closely linked to signaling by cyclic nucleotides and their associated kinases. This Review summarizes the pivotal roles that calcium- and cyclic nucleotide-dependent kinases play in unique aspects of parasite biology.
AB - Calcium controls many critical events in the complex life cycles of apicomplexan parasites including protein secretion, motility, and development. Calcium levels are normally tightly regulated and rapid release of calcium into the cytosol activates a family of calcium-dependent protein kinases (CDPKs), which are normally characteristic of plants. CDPKs present in apicomplexans have acquired a number of unique domain structures likely reflecting their diverse functions. Calcium regulation in parasites is closely linked to signaling by cyclic nucleotides and their associated kinases. This Review summarizes the pivotal roles that calcium- and cyclic nucleotide-dependent kinases play in unique aspects of parasite biology.
UR - http://www.scopus.com/inward/record.url?scp=67649399023&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2009.05.017
DO - 10.1016/j.chom.2009.05.017
M3 - Review article
C2 - 19527888
AN - SCOPUS:67649399023
SN - 1931-3128
VL - 5
SP - 612
EP - 622
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 6
ER -