Abstract
The authors show that thioridazine possesses calcium antagonist activity which may relate to its cardiac and sexual side effects. Binding sites associated with voltage-operated calcium channels were labeled by 3H-nitrendipine. Thioridazine influenced this binding of 3H-nitrendipine in a fashion similar to known calcium antagonists such as verapamil. Thioridazine also antagonized potassium-induced, calcium-dependent contractions of rat vas deferens, with similar potency. Thioridazine concentrations that exert calcium channel antagonist effect correspond to blood levels at therapeutic doses.
Original language | English |
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Pages (from-to) | 352-357 |
Number of pages | 6 |
Journal | American Journal of Psychiatry |
Volume | 141 |
Issue number | 3 |
DOIs | |
State | Published - 1984 |