Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis

Avik Som; Ramesh Raliya; Krishna Paranandi; Rachel A. High; Nathan Reed; Scott C. Beeman; Matthew Brandenburg; Gail Sudlow; Julie L. Prior; Walter Akers; Annelise Y. Mah-Som; Lemoyne Habimana-Griffin; Joel Garbow; Joseph E. Ippolito; Mark D. Pagel; Pratim Biswas; Samuel Achilefu

doi:10.2217/nnm-2018-0302

Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis

Avik Som, Ramesh Raliya, Krishna Paranandi, Rachel A. High, Nathan Reed, Scott C. Beeman, Matthew Brandenburg, Gail Sudlow, Julie L. Prior, Walter Akers, Annelise Y. Mah-Som, Lemoyne Habimana-Griffin, Joel Garbow, Joseph E. Ippolito, Mark D. Pagel, Pratim Biswas, Samuel Achilefu

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Aim: CaCO₃ nanoparticles (nano-CaCO₃) can neutralize the acidic pHe of solid tumors, but the lack of intrinsic imaging signal precludes noninvasive monitoring of pH-perturbation in tumor microenvironment. We aim to develop a theranostic version of nano-CaCO₃ to noninvasively monitor pH modulation and subsequent tumor response. Materials & methods: We synthesized ferromagnetic core coated with CaCO₃ (magnetite CaCO₃). Magnetic resonance imaging (MRI) was used to determine the biodistribution and pH modulation using murine fibrosarcoma and breast cancer models. Results: Magnetite CaCO₃-MRI imaging showed that nano-CaCO₃ rapidly raised tumor pHe, followed by excessive tumor-associated acid production after its clearance. Continuous nano-CaCO₃ infusion could inhibit metastasis. Conclusion: Nano-CaCO₃ exposure induces tumor metabolic reprogramming that could account for the failure of previous intermittent pH-modulation strategies to achieve sustainable therapeutic effect.

Original language	English
Pages (from-to)	169-182
Number of pages	14
Journal	Nanomedicine
Volume	14
Issue number	2
DOIs	https://doi.org/10.2217/nnm-2018-0302
State	Published - Jan 1 2019

Keywords

MRI
magnetite
nano-CaCO
pH modulation
theranostic

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Som, A., Raliya, R., Paranandi, K., High, R. A., Reed, N., Beeman, S. C., Brandenburg, M., Sudlow, G., Prior, J. L., Akers, W., Mah-Som, A. Y., Habimana-Griffin, L., Garbow, J., Ippolito, J. E., Pagel, M. D., Biswas, P., & Achilefu, S. (2019). Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis. Nanomedicine, 14(2), 169-182. https://doi.org/10.2217/nnm-2018-0302

@article{40bc6794038a48e68fec3fbf6657a7ac,

title = "Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis",

abstract = "Aim: CaCO3 nanoparticles (nano-CaCO3) can neutralize the acidic pHe of solid tumors, but the lack of intrinsic imaging signal precludes noninvasive monitoring of pH-perturbation in tumor microenvironment. We aim to develop a theranostic version of nano-CaCO3 to noninvasively monitor pH modulation and subsequent tumor response. Materials & methods: We synthesized ferromagnetic core coated with CaCO3 (magnetite CaCO3). Magnetic resonance imaging (MRI) was used to determine the biodistribution and pH modulation using murine fibrosarcoma and breast cancer models. Results: Magnetite CaCO3-MRI imaging showed that nano-CaCO3 rapidly raised tumor pHe, followed by excessive tumor-associated acid production after its clearance. Continuous nano-CaCO3 infusion could inhibit metastasis. Conclusion: Nano-CaCO3 exposure induces tumor metabolic reprogramming that could account for the failure of previous intermittent pH-modulation strategies to achieve sustainable therapeutic effect.",

keywords = "MRI, magnetite, nano-CaCO, pH modulation, theranostic",

author = "Avik Som and Ramesh Raliya and Krishna Paranandi and High, {Rachel A.} and Nathan Reed and Beeman, {Scott C.} and Matthew Brandenburg and Gail Sudlow and Prior, {Julie L.} and Walter Akers and Mah-Som, {Annelise Y.} and Lemoyne Habimana-Griffin and Joel Garbow and Ippolito, {Joseph E.} and Pagel, {Mark D.} and Pratim Biswas and Samuel Achilefu",

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year = "2019",

month = jan,

day = "1",

doi = "10.2217/nnm-2018-0302",

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volume = "14",

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journal = "Nanomedicine",

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Som, A, Raliya, R, Paranandi, K, High, RA, Reed, N, Beeman, SC, Brandenburg, M, Sudlow, G, Prior, JL, Akers, W, Mah-Som, AY, Habimana-Griffin, L, Garbow, J , Ippolito, JE, Pagel, MD, Biswas, P & Achilefu, S 2019, 'Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis', Nanomedicine, vol. 14, no. 2, pp. 169-182. https://doi.org/10.2217/nnm-2018-0302

TY - JOUR

T1 - Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis

AU - Som, Avik

AU - Raliya, Ramesh

AU - Paranandi, Krishna

AU - High, Rachel A.

AU - Reed, Nathan

AU - Beeman, Scott C.

AU - Brandenburg, Matthew

AU - Sudlow, Gail

AU - Prior, Julie L.

AU - Akers, Walter

AU - Mah-Som, Annelise Y.

AU - Habimana-Griffin, Lemoyne

AU - Garbow, Joel

AU - Ippolito, Joseph E.

AU - Pagel, Mark D.

AU - Biswas, Pratim

AU - Achilefu, Samuel

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim: CaCO3 nanoparticles (nano-CaCO3) can neutralize the acidic pHe of solid tumors, but the lack of intrinsic imaging signal precludes noninvasive monitoring of pH-perturbation in tumor microenvironment. We aim to develop a theranostic version of nano-CaCO3 to noninvasively monitor pH modulation and subsequent tumor response. Materials & methods: We synthesized ferromagnetic core coated with CaCO3 (magnetite CaCO3). Magnetic resonance imaging (MRI) was used to determine the biodistribution and pH modulation using murine fibrosarcoma and breast cancer models. Results: Magnetite CaCO3-MRI imaging showed that nano-CaCO3 rapidly raised tumor pHe, followed by excessive tumor-associated acid production after its clearance. Continuous nano-CaCO3 infusion could inhibit metastasis. Conclusion: Nano-CaCO3 exposure induces tumor metabolic reprogramming that could account for the failure of previous intermittent pH-modulation strategies to achieve sustainable therapeutic effect.

AB - Aim: CaCO3 nanoparticles (nano-CaCO3) can neutralize the acidic pHe of solid tumors, but the lack of intrinsic imaging signal precludes noninvasive monitoring of pH-perturbation in tumor microenvironment. We aim to develop a theranostic version of nano-CaCO3 to noninvasively monitor pH modulation and subsequent tumor response. Materials & methods: We synthesized ferromagnetic core coated with CaCO3 (magnetite CaCO3). Magnetic resonance imaging (MRI) was used to determine the biodistribution and pH modulation using murine fibrosarcoma and breast cancer models. Results: Magnetite CaCO3-MRI imaging showed that nano-CaCO3 rapidly raised tumor pHe, followed by excessive tumor-associated acid production after its clearance. Continuous nano-CaCO3 infusion could inhibit metastasis. Conclusion: Nano-CaCO3 exposure induces tumor metabolic reprogramming that could account for the failure of previous intermittent pH-modulation strategies to achieve sustainable therapeutic effect.

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KW - magnetite

KW - nano-CaCO

KW - pH modulation

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SN - 1743-5889

VL - 14

SP - 169

EP - 182

JO - Nanomedicine

JF - Nanomedicine

IS - 2

ER -

Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis

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Keywords

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