TY - JOUR
T1 - Calcifediol in Chronic Renal Insufficiency
T2 - Skeletal Response
AU - Teitelbaum, Steven L.
AU - Bone, J. Michael
AU - Stein, Paul M.
AU - Gilden, Jerome J.
AU - Bates, Margaret
AU - Boisseau, Vincenza C.
AU - Avioli, Louis V.
PY - 1976/1/12
Y1 - 1976/1/12
N2 - Quantitative histology of thin, nondecalcified sections was performed on squential bone biopsy specimens from five patients undergoing long-term hemodialysis and treated with calcifediol (25-hydroxycholecalciferol) for periods of three to nine months. With increase of intestinal absorption of calcium and decline of circulating immunoreactive parathyroid hormone and alkaline phosphatase, the bones of each patient exhibited striking histological improvement. The group as a whole showed statistically significant decreases in osteoclast number and in the percentages of osteoid surface covered by active osteoblasts. Marrow fibrosis was either eliminated or strikingly decreased in each patient. Osteoid volume significantly declined in four of five patients. In patients with osteitis fibrosa as the predominant histological lesion, calcifediol therapy resulted in decreased calcification front activity. Increased activity was the result when osteomalacia predominated.
AB - Quantitative histology of thin, nondecalcified sections was performed on squential bone biopsy specimens from five patients undergoing long-term hemodialysis and treated with calcifediol (25-hydroxycholecalciferol) for periods of three to nine months. With increase of intestinal absorption of calcium and decline of circulating immunoreactive parathyroid hormone and alkaline phosphatase, the bones of each patient exhibited striking histological improvement. The group as a whole showed statistically significant decreases in osteoclast number and in the percentages of osteoid surface covered by active osteoblasts. Marrow fibrosis was either eliminated or strikingly decreased in each patient. Osteoid volume significantly declined in four of five patients. In patients with osteitis fibrosa as the predominant histological lesion, calcifediol therapy resulted in decreased calcification front activity. Increased activity was the result when osteomalacia predominated.
UR - http://www.scopus.com/inward/record.url?scp=0017304844&partnerID=8YFLogxK
U2 - 10.1001/jama.1976.03260280022019
DO - 10.1001/jama.1976.03260280022019
M3 - Article
C2 - 946022
AN - SCOPUS:0017304844
SN - 0098-7484
VL - 235
SP - 164
EP - 167
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 2
ER -