TY - JOUR
T1 - C4d peritubular capillary staining in chronic allograft nephropathy and transplant glomerulopathy
T2 - An uncommon finding
AU - Al Aly, Ziyad
AU - Yalamanchili, Praveen
AU - Cortese, Cherise
AU - Salinas-Madrigal, Luis
AU - Bastani, Bahar
PY - 2005/7
Y1 - 2005/7
N2 - The true incidence of positive C4d staining in the peritubular capillaries of biopsies with chronic allograft nephropathy (CAN) and transplant glomerulopathy (TGP) remains controversial. We retrospectively reviewed all transplant biopsies performed at Saint Louis University Hospital between June 2002 and May 2004. We examined the incidence of positive C4d staining in the peritubular capillaries of biopsy specimens with pure CAN with or without features of TGP. We identified 54 biopsies in 43 patients showing CAN. The average age was 46 ± 13 years. The average creatinine at the time of biopsy was 308 ± 211 μmol/l (3.5 ± 2.4 mg/dl). Twenty (37%) biopsies exhibited features consistent with TGP. Only two biopsies had positive C4d staining in the peritubular capillaries. The C4d positive biopsies were from two different patients; one patient had donor specific antibodies (DSA) against HLA class 1 at the time of biopsy and the other patient had no detectable DSA. None of the TGP biopsies showed peritubular C4d staining. C4d staining of the peritubular capillaries appears to be rare in patients with pure CAN with and without TGP features.
AB - The true incidence of positive C4d staining in the peritubular capillaries of biopsies with chronic allograft nephropathy (CAN) and transplant glomerulopathy (TGP) remains controversial. We retrospectively reviewed all transplant biopsies performed at Saint Louis University Hospital between June 2002 and May 2004. We examined the incidence of positive C4d staining in the peritubular capillaries of biopsy specimens with pure CAN with or without features of TGP. We identified 54 biopsies in 43 patients showing CAN. The average age was 46 ± 13 years. The average creatinine at the time of biopsy was 308 ± 211 μmol/l (3.5 ± 2.4 mg/dl). Twenty (37%) biopsies exhibited features consistent with TGP. Only two biopsies had positive C4d staining in the peritubular capillaries. The C4d positive biopsies were from two different patients; one patient had donor specific antibodies (DSA) against HLA class 1 at the time of biopsy and the other patient had no detectable DSA. None of the TGP biopsies showed peritubular C4d staining. C4d staining of the peritubular capillaries appears to be rare in patients with pure CAN with and without TGP features.
KW - Allo-immune rejection
KW - C4d
KW - Chronic allograft nephropathy
KW - Chronic rejection
KW - Complement split product
KW - Humoral rejection
KW - Transplant glomerulopathy
UR - http://www.scopus.com/inward/record.url?scp=26044445789&partnerID=8YFLogxK
U2 - 10.1111/j.1432-2277.2005.00130.x
DO - 10.1111/j.1432-2277.2005.00130.x
M3 - Review article
C2 - 15948858
AN - SCOPUS:26044445789
SN - 0934-0874
VL - 18
SP - 800
EP - 805
JO - Transplant International
JF - Transplant International
IS - 7
ER -