@article{392d1fc6e5f74c56a755d17c35059d5e,
title = "C-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells",
abstract = "Although the transcription factor c-Myc is essential for the establishment of a metabolically active and proliferative state in T cells after priming, its expression is transient. It remains unknown how T cell activation is maintained after c-Myc expression is downregulated. Here we identified AP4 as the transcription factor that was induced by c-Myc and sustained activation of antigen-specific CD8+ T cells. Despite normal priming, AP4-deficient CD8+ T cells failed to continue transcription of a broad range of c-Myc-dependent targets. Mice lacking AP4 specifically in CD8+ T cells showed enhanced susceptibility to infection with West Nile virus. Genome-wide analysis suggested that many activation-induced genes encoding molecules involved in metabolism were shared targets of c-Myc and AP4. Thus, AP4 maintains c-Myc-initiated cellular activation programs in CD8+ T cells to control microbial infection.",
author = "Chun Chou and Pinto, {Amelia K.} and Curtis, {Jonathan D.} and Persaud, {Stephen P.} and Marina Cella and Lin, {Chih Chung} and Edelson, {Brian T.} and Allen, {Paul M.} and Marco Colonna and Pearce, {Erika L.} and Diamond, {Michael S.} and Takeshi Egawa",
note = "Funding Information: We thank M.J. Bevan (University of Washington, Seattle) for LM-OVA; I. Taniuchi (RIKEN, Yokohama) and D.R. Littman (New York University) for CD8-Cre mice; B.P. Sleckman (Washington University School of Medicine) for c-Myc–GFP knock-in mice; F.W. Alt (Harvard Medical School) and D.R. Green (St. Jude Children{\textquoteright}s Research Hospital) for MycF mice; T. Hansen (Washington University School of Medicine) for the H-2Kb–OVA single-chain tetramer; S. Hsiung, J. Govero and M.J. Sunshine for technical assistance; and E. Oltz, C.-S. Hsieh and D.R. Littman for discussions and critical reading of the manuscript. Supported by the Lucille P. Markey Pathway Program (C.C.), the Burroughs Wellcome Fund (B.T.E.), the McDonnell International Scholars Academy at Washington University (C.-C.L.), the US National Institutes of Health (P30 AR048335 to the Rheumatic Diseases Core Center; R01 AI097244 to T.E.; and U54 AI081680 to M.S.D.), the Edward Mallinckrodt Jr. Foundation (T.E.) and the Washington University Institute of Clinical and Translational Sciences of the National Center for Advancing Translational Sciences of the US National Institutes of Health (UL1 TR000448).",
year = "2014",
month = sep,
doi = "10.1038/ni.2943",
language = "English",
volume = "15",
pages = "884--893",
journal = "Nature immunology",
issn = "1529-2908",
number = "9",
}