C-Glycosides, Array-based Addressable Libraries, and the Versatility of Constant Current Electrochemistry

Constant current electrochemical reactions are very versatile tools for conducting oxidation and reduction reactions. In the reactions, the potential at the working electrode automatically adjusts to that of the substrate in solution, a situation that allows for the same overall synthetic approach to be used for both the direct oxidation and reduction of substrates and the generation of a wide range of chemical reagents and catalysts. The science presented in this manuscript illustrates how a combination of these methods can be used to create new opportunities for synthesis. Specifically, a direct constant current electrolysis was used to synthesize C-glycoside derivatives that were then placed site-selectively on a microelectrode array by using the same overall electrochemical approach to generate chemical reagents.