Buspirone: Chemistry, pharmacology, and behavior

P. Skolnick, S. M. Paul

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Recent neurochemical and behavioral observations with the nonbenzodiazepine anxiolytic buspirone raise several issues of importance to neuroscientists. These include: (1) the role of a GABA-benzodiazepine receptor-chloride ionophore complex in the actions of buspirone and other anxiolytics; (2) the involvement of dopaminergi-pathways in mediating anxiety and/or anxiolytic actions; and (3) the existence of a common pre- or postreceptor 'effector system' for buspirone and other antianxiety agents. These issues are critically discussed in light of recent findings.

Original languageEnglish
Pages (from-to)40-44
Number of pages5
JournalJournal of Clinical Psychiatry
Issue number12 II
StatePublished - Dec 1 1982


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