Recent neurochemical and behavioral observations with the nonbenzodiazepine anxiolytic buspirone raise several issues of importance to neuroscientists. These include: (1) the role of a GABA-benzodiazepine receptor-chloride ionophore complex in the actions of buspirone and other anxiolytics; (2) the involvement of dopaminergi-pathways in mediating anxiety and/or anxiolytic actions; and (3) the existence of a common pre- or postreceptor 'effector system' for buspirone and other antianxiety agents. These issues are critically discussed in light of recent findings.
|Number of pages||5|
|Journal||Journal of Clinical Psychiatry|
|Issue number||12 II|
|State||Published - Dec 1 1982|