Buspirone attenuates learned helplessness behavior in rats

Robert C. Drugan, Jacqueline N. Crawley, Steven M. Paul, Phil Skolnick

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Rats pretreated with either chlordiazepoxide (5 mg/kg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805) (2 or 5 mg/kg) did not block this shock‐induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalDrug Development Research
Volume10
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • anxiety
  • buspirone
  • depression
  • gepirone

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