Bulk optical properties of healthy female breast tissue

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, A. G. Yodh

Research output: Contribution to journalArticle

250 Scopus citations

Abstract

We have measured the bulk optical properties of healthy female breast tissues in vivo in the parallel plate, transmission geometry. Fifty-two volunteers were measured. Blood volume and blood oxygen saturation were derived from the optical property data using a novel method that employed a priori spectral information to overcome limitations associated with simple homogeneous tissue models. The measurements provide an estimate of the variation of normal breast tissue optical properties in a fairly large population. The mean blood volume was 34 ± 9 μM and the mean blood oxygen saturation was 68 ± 8%. We also investigated the correlation of these optical properties with demographic factors such as body mass index (BMI) and age. We observed a weak correlation of blood volume and reduced scattering coefficient with BMI; correlation with age, however, was not evident within the statistical error of these experiments. The new information on healthy breast tissue provides insight about the potential contrasts available for diffuse optical tomography of breast tumours.

Original languageEnglish
Pages (from-to)2847-2861
Number of pages15
JournalPhysics in medicine and biology
Volume47
Issue number16
DOIs
StatePublished - Aug 21 2002
Externally publishedYes

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    Durduran, T., Choe, R., Culver, J. P., Zubkov, L., Holboke, M. J., Giammarco, J., Chance, B., & Yodh, A. G. (2002). Bulk optical properties of healthy female breast tissue. Physics in medicine and biology, 47(16), 2847-2861. https://doi.org/10.1088/0031-9155/47/16/302