Building the immunological synapse - toward a quantitative view of T cell activation

Michael L. Dustin, Shannon K. Bromley, Arash Grakoui, Paul Allen, Cenk Sumen, Mark Davis, Andrey S. Shaw

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A model system has been developed to study the role of segregation in T cell activation. The system involves the formation of an immunological synapse that is quantitatively visualized in real time. Supported planar bilayers were prepared with fluorescently labeled MHC-peptide complexes and adhesion molecules. Molecular segregation of engaged MHC-peptide and ICAM-1 complexes was strongly correlated with T cell proliferation. These data support the hypothesis that molecular segregation is important for T cell signaling.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Conference

ConferenceProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

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