@inproceedings{8e28fc9494d44557b5f073885fecd101,
title = "Building the immunological synapse - toward a quantitative view of T cell activation",
abstract = "A model system has been developed to study the role of segregation in T cell activation. The system involves the formation of an immunological synapse that is quantitatively visualized in real time. Supported planar bilayers were prepared with fluorescently labeled MHC-peptide complexes and adhesion molecules. Molecular segregation of engaged MHC-peptide and ICAM-1 complexes was strongly correlated with T cell proliferation. These data support the hypothesis that molecular segregation is important for T cell signaling.",
author = "Dustin, {Michael L.} and Bromley, {Shannon K.} and Arash Grakoui and Paul Allen and Cenk Sumen and Mark Davis and Shaw, {Andrey S.}",
year = "1999",
month = dec,
day = "1",
language = "English",
isbn = "0780356756",
series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "IEEE",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
note = "Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) ; Conference date: 13-10-1999 Through 16-10-1999",
}