Building Chemical Probes Based on the Natural Products YM-254890 and FR900359: Advances toward Scalability

Matthew R. Medcalf; Ruby L. Krueger; Zach T. Medcalf; Peter A. Rosston; Yu Zhu; Kevin M. Kaltenbronn; Kendall J. Blumer; Kevin D. Moeller

doi:10.1055/a-1873-6891

Building Chemical Probes Based on the Natural Products YM-254890 and FR900359: Advances toward Scalability

Matthew R. Medcalf, Ruby L. Krueger, Zach T. Medcalf, Peter A. Rosston, Yu Zhu, Kevin M. Kaltenbronn, Kendall J. Blumer, Kevin D. Moeller

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The biological activity of natural products YM-254890 (YM) and FR900359 (FR) has led to significant interest in both their synthesis and the construction of more simplified analogs. While the simplified analogs lose much of the potency of the natural products, they are of interest in their own right, and their synthesis has revealed synthetic barriers to the family of molecules that need to be addressed if a scalable synthesis of YM and FR analogs is to be constructed. In the work described here, a synthetic route to simplified analogs of YM is examined and strategies for circumventing some of the challenges inherent to constructing the molecules are forwarded.

Original language	English
Pages (from-to)	90-106
Number of pages	17
Journal	Synthesis
Volume	55
Issue number	1
DOIs	https://doi.org/10.1055/a-1873-6891
State	Published - Apr 25 2022

Keywords

FR900359
YM-254890
analogs
scalable synthesis

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10.1055/a-1873-6891

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abstract = "The biological activity of natural products YM-254890 (YM) and FR900359 (FR) has led to significant interest in both their synthesis and the construction of more simplified analogs. While the simplified analogs lose much of the potency of the natural products, they are of interest in their own right, and their synthesis has revealed synthetic barriers to the family of molecules that need to be addressed if a scalable synthesis of YM and FR analogs is to be constructed. In the work described here, a synthetic route to simplified analogs of YM is examined and strategies for circumventing some of the challenges inherent to constructing the molecules are forwarded.",

keywords = "FR900359, YM-254890, analogs, scalable synthesis",

author = "Medcalf, {Matthew R.} and Krueger, {Ruby L.} and Medcalf, {Zach T.} and Rosston, {Peter A.} and Yu Zhu and Kaltenbronn, {Kevin M.} and Blumer, {Kendall J.} and Moeller, {Kevin D.}",

note = "Funding Information: We thank the National Institutes of Health (2R01GM124093) for their generous support of our work. Publisher Copyright: {\textcopyright} 2022 Georg Thieme Verlag. All rights reserved.",

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Building Chemical Probes Based on the Natural Products YM-254890 and FR900359: Advances toward Scalability

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Keywords

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