Building addressable libraries: Spatially isolated, chip-based reductive amination reactions

Eden Tesfu; Karl Maurer; Kevin D. Moeller

doi:10.1021/ja057155x

Building addressable libraries: Spatially isolated, chip-based reductive amination reactions

Eden Tesfu, Karl Maurer, Kevin D. Moeller

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A Pd(II) reagent has been generated at preselected sites on an electrochemically addressable chip and used to effect the oxidation of the neighboring alcohols on the polymer coating the chip's surface. The resulting carbonyls were then used to accomplish site-selective reductive amination reactions on the chips. The work demonstrates that the confinement strategy developed for spatially isolated Wacker oxidations to specific sites on the chips is general and can be used for other Pd(II)-based reactions.

Original language	English
Pages (from-to)	70-71
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	1
DOIs	https://doi.org/10.1021/ja057155x
State	Published - Jan 11 2006

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10.1021/ja057155x

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Building addressable libraries: Spatially isolated, chip-based reductive amination reactions

Abstract

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