Building addressable libraries: Site-selective lewis acid (Seandium(III)) catalyzed reactions

Bo Bi, Karl Maurer, Kevin D. Moeller

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Reagent confinement: Lewis acid catalyzed reactions have been conducted on arrays with either 1024 or 12 544 microelectrodes cm-2. A Sc III species generated at the electrodes is employed as the Lewis acid, and the reagent is confined to the electrodes through the use of a solutionphase reductant. A multicomponent synthesis of a tetrahydropyran (see scheme), a Diels-Alder reaction, and an esterification reaction are all compatible with this strategy.

Original languageEnglish
Pages (from-to)5872-5874
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number32
StatePublished - Jul 27 2009


  • Diels-Alder reactions
  • Lewis acids
  • Microelectrode arrays
  • Multicomponent reactions
  • Site-selective synthesis


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