TY - JOUR
T1 - Building addressable libraries
T2 - Site-selective lewis acid (Seandium(III)) catalyzed reactions
AU - Bi, Bo
AU - Maurer, Karl
AU - Moeller, Kevin D.
PY - 2009/7/27
Y1 - 2009/7/27
N2 - Reagent confinement: Lewis acid catalyzed reactions have been conducted on arrays with either 1024 or 12 544 microelectrodes cm-2. A Sc III species generated at the electrodes is employed as the Lewis acid, and the reagent is confined to the electrodes through the use of a solutionphase reductant. A multicomponent synthesis of a tetrahydropyran (see scheme), a Diels-Alder reaction, and an esterification reaction are all compatible with this strategy.
AB - Reagent confinement: Lewis acid catalyzed reactions have been conducted on arrays with either 1024 or 12 544 microelectrodes cm-2. A Sc III species generated at the electrodes is employed as the Lewis acid, and the reagent is confined to the electrodes through the use of a solutionphase reductant. A multicomponent synthesis of a tetrahydropyran (see scheme), a Diels-Alder reaction, and an esterification reaction are all compatible with this strategy.
KW - Diels-Alder reactions
KW - Lewis acids
KW - Microelectrode arrays
KW - Multicomponent reactions
KW - Site-selective synthesis
UR - http://www.scopus.com/inward/record.url?scp=70349914297&partnerID=8YFLogxK
U2 - 10.1002/anie.200902350
DO - 10.1002/anie.200902350
M3 - Article
C2 - 19582751
AN - SCOPUS:70349914297
SN - 1433-7851
VL - 48
SP - 5872
EP - 5874
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 32
ER -