Buccal Epithelium, Cigarette Smoking, and Lung Cancer: Review of the Literature

Raya Saba, Oleksandr Halytskyy, Nasir Saleem, Ira A. Oliff

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Lung cancer is currently the leading cause of cancer-related mortality among men and women in the United States, and optimal screening methods are still lacking. The field effect is a well-supported phenomenon wherein a noxious stimulus triggers genetic, epigenetic and molecular changes that are widespread throughout the entire exposed organ system. The buccal epithelium is an easily accessible part of the respiratory tree that has good potential of yielding a surrogate marker for the field effect in cigarette smokers, and thus, a noninvasive, reliable lung cancer screening method. Herein, we review the literature on the relationship between the buccal epithelium, cigarette smoking, and lung cancer.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalOncology (Switzerland)
Issue number6
StatePublished - Dec 1 2017


  • Buccal epithelium
  • Lung cancer
  • Screening
  • Smoking


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