TY - JOUR
T1 - BST-2/tetherin
T2 - Structural biology, viral antagonism, and immunobiology of a potent host antiviral factor
AU - Swiecki, Melissa
AU - Omattage, Natalie S.
AU - Brett, Tom J.
PY - 2013/6
Y1 - 2013/6
N2 - BST-2 (also known as tetherin, CD317, or HM1.24) was first described as a potent interferon-inducible host antiviral factor nearly five years ago. Since that time, numerous reports have been published regarding the antiviral activity and immunological properties of this protein. BST-2 blocks viral replication by inhibiting enveloped virus budding from the surface of infected cells. To counteract this, most viruses have developed strategies to antagonize BST-2, each employing a unique mechanism. In this review, we summarize the antiviral function, structural biology and immunobiology of BST-2. Taken together, our current understanding of BST-2 suggests potential avenues as well as challenges to exploiting its action in the development of broad spectrum antiviral treatments.
AB - BST-2 (also known as tetherin, CD317, or HM1.24) was first described as a potent interferon-inducible host antiviral factor nearly five years ago. Since that time, numerous reports have been published regarding the antiviral activity and immunological properties of this protein. BST-2 blocks viral replication by inhibiting enveloped virus budding from the surface of infected cells. To counteract this, most viruses have developed strategies to antagonize BST-2, each employing a unique mechanism. In this review, we summarize the antiviral function, structural biology and immunobiology of BST-2. Taken together, our current understanding of BST-2 suggests potential avenues as well as challenges to exploiting its action in the development of broad spectrum antiviral treatments.
KW - Antiviral state
KW - Innate immunity
KW - Interferon
KW - Plasmacytoid dendritic cells
KW - Tetherin
KW - Virology
UR - http://www.scopus.com/inward/record.url?scp=84871648210&partnerID=8YFLogxK
U2 - 10.1016/j.molimm.2012.11.008
DO - 10.1016/j.molimm.2012.11.008
M3 - Review article
C2 - 23274150
AN - SCOPUS:84871648210
SN - 0161-5890
VL - 54
SP - 132
EP - 139
JO - Molecular Immunology
JF - Molecular Immunology
IS - 2
ER -