TY - JOUR
T1 - Brown fat fuels the fire in fever
AU - Krysa, Samantha J.
AU - Brestoff, Jonathan R.
N1 - Publisher Copyright:
© 2024 THE AUTHORS.
PY - 2024/11
Y1 - 2024/11
N2 - Fever is a host-pathogen defense mechanism in which the immune system drives a physiologic increase in core body temperature. For over 50 years, it has been known that the temperature of brown adipose tissue (BAT) is increased during the febrile response. However, recent studies suggested that the primary thermogenic protein Uncoupling protein 1 in brown adipocytes does not contribute to fever induction in mice, casting doubt about the functional contribution of BAT to fever. In a new set of studies, Li et al. (2024) provide compelling evidence that fatty acid oxidation is markedly increased in BAT in a Salmonella infection model of fever and strongly suggest that metabolic adaptation in BAT may play a critical role in the febrile response. This article re-opens the debate about how thermogenic and metabolic programs in BAT contribute to fever and raises new questions about whether BAT contributes to host defense against pathogens.
AB - Fever is a host-pathogen defense mechanism in which the immune system drives a physiologic increase in core body temperature. For over 50 years, it has been known that the temperature of brown adipose tissue (BAT) is increased during the febrile response. However, recent studies suggested that the primary thermogenic protein Uncoupling protein 1 in brown adipocytes does not contribute to fever induction in mice, casting doubt about the functional contribution of BAT to fever. In a new set of studies, Li et al. (2024) provide compelling evidence that fatty acid oxidation is markedly increased in BAT in a Salmonella infection model of fever and strongly suggest that metabolic adaptation in BAT may play a critical role in the febrile response. This article re-opens the debate about how thermogenic and metabolic programs in BAT contribute to fever and raises new questions about whether BAT contributes to host defense against pathogens.
KW - BAT
KW - Brown adipose tissue
KW - fatty acid oxidation
KW - febrile
KW - fever
KW - immunometabolism
UR - http://www.scopus.com/inward/record.url?scp=85208372962&partnerID=8YFLogxK
U2 - 10.1016/j.jlr.2024.100658
DO - 10.1016/j.jlr.2024.100658
M3 - Review article
C2 - 39332526
AN - SCOPUS:85208372962
SN - 0022-2275
VL - 65
JO - Journal of lipid research
JF - Journal of lipid research
IS - 11
M1 - 100658
ER -