Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice

Caryn Carson, Juan F. Macias-Velasco, Subhadra Gunawardana, Mario A. Miranda, Sakura Oyama, Celine L. St. Pierre, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We leverage the SM/J mouse to understand glycemic control in obesity. High-fat-fed SM/J mice initially develop poor glucose homeostasis relative to controls. Strikingly, their glycemic dysfunction resolves by 30 weeks of age despite persistent obesity. The mice dramatically expand their brown adipose depots as they resolve glycemic dysfunction. This occurs naturally and spontaneously on a high-fat diet, with no temperature or genetic manipulation. Removal of the brown adipose depot impairs insulin sensitivity, indicating that the expanded tissue is functioning as an insulin-stimulated glucose sink. We describe morphological, physiological, and transcriptomic changes that occur during the brown adipose expansion and remission of glycemic dysfunction, and focus on Sfrp1 (secreted frizzled-related protein 1) as a compelling candidate that may underlie this phenomenon. Understanding how the expanded brown adipose contributes to glycemic control in SM/J mice will open the door for innovative therapies aimed at improving metabolic complications in obesity.

Original languageEnglish
Article number108237
JournalCell Reports
Volume33
Issue number1
DOIs
StatePublished - Oct 6 2020

Keywords

  • brown adipose
  • glycemic control
  • insulin sensitivity
  • metabolism
  • mouse model
  • obesity
  • transcriptome

Fingerprint

Dive into the research topics of 'Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice'. Together they form a unique fingerprint.

Cite this