@article{ab6b86bf4d5b4847b55d51937fbfb1c4,
title = "Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice",
abstract = "We leverage the SM/J mouse to understand glycemic control in obesity. High-fat-fed SM/J mice initially develop poor glucose homeostasis relative to controls. Strikingly, their glycemic dysfunction resolves by 30 weeks of age despite persistent obesity. The mice dramatically expand their brown adipose depots as they resolve glycemic dysfunction. This occurs naturally and spontaneously on a high-fat diet, with no temperature or genetic manipulation. Removal of the brown adipose depot impairs insulin sensitivity, indicating that the expanded tissue is functioning as an insulin-stimulated glucose sink. We describe morphological, physiological, and transcriptomic changes that occur during the brown adipose expansion and remission of glycemic dysfunction, and focus on Sfrp1 (secreted frizzled-related protein 1) as a compelling candidate that may underlie this phenomenon. Understanding how the expanded brown adipose contributes to glycemic control in SM/J mice will open the door for innovative therapies aimed at improving metabolic complications in obesity.",
keywords = "brown adipose, glycemic control, insulin sensitivity, metabolism, mouse model, obesity, transcriptome",
author = "Caryn Carson and Macias-Velasco, {Juan F.} and Subhadra Gunawardana and Miranda, {Mario A.} and Sakura Oyama and {St. Pierre}, {Celine L.} and Heather Schmidt and Wayhart, {Jessica P.} and Lawson, {Heather A.}",
note = "Funding Information: This work was supported by the Washington University Department of Genetics , the Diabetes Research Center at Washington University (grant P30DK020579 ), the NIH NIDDK (grant K01 DK095003 to H.A.L.), and NIH NIGM (grant T32 GM007067 to C.C.). Funding Information: This work was supported by the Washington University Department of Genetics, the Diabetes Research Center at Washington University (grant P30DK020579), the NIH NIDDK (grant K01 DK095003 to H.A.L.), and NIH NIGM (grant T32 GM007067 to C.C.). H.A.L. and C.C. designed the experiments. C.C. H.S. J.P.W. and H.A.L. performed physiological and molecular assays. C.C. M.A.M. and S.O. performed histological assays and analyses. C.C. and S.G. performed excision surgeries. C.C. J.F.M.-V. C.L.S.P. and H.A.L. analyzed the RNA-seq data. C.C. and H.A.L. wrote the manuscript. All authors edited and approved the final draft. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = oct,
day = "6",
doi = "10.1016/j.celrep.2020.108237",
language = "English",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
number = "1",
}