TY - JOUR
T1 - Bronchial Thermoplasty
AU - Mainardi, Anne S.
AU - Castro, Mario
AU - Chupp, Geoffrey
N1 - Funding Information:
Disclosure Statement: A.S. Mainardi has no financial relationships to disclose. Dr. Castro receives University Grant Funding from NIH, American Lung Association, PCORI. He receives Pharmaceutical Grant Funding from AstraZeneca, Boeringer Ingelheim, Chiesi, GSK, Novartis, Sanofi Aventis. He is a consultant for Aviragen, Boston Scientific, Genentech, Nuvaira, Neutronic, Therabron, Theravance, Vectura, 4D Pharma, VIDA, Mallincrodt, Teva, Sanofi-Aventis. He is a speaker for Astra-Zeneca, Boeringer Ingelheim, Boston Scientific, Genentech, Regeneron, Sanofi, Teva. He receives royalties from Elsevier. G. Chupp reports receiving honoraria for advisory board and speaker bureau activity from Astra Zeneca, Glaxo-Smith-Kline, Genentech, Teva, Boehringer-Ingelheim, and Circassia.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/3
Y1 - 2019/3
N2 - Bronchial thermoplasty is an advanced therapy for severe asthma. It is a bronchoscopic procedure in which radiofrequency energy is applied to the airway wall, resulting in decreased airway smooth muscle burden. Human trials have shown that bronchial thermoplasty may reduce asthma exacerbations and improve quality of life in patients with severe uncontrolled asthma. It has been demonstrated to be a safe procedure, with most adverse events being early and mild. More studies are required to understand the precise effects of bronchial thermoplasty on the asthmatic airway and optimal parameters to appropriately select patients for this novel procedure.
AB - Bronchial thermoplasty is an advanced therapy for severe asthma. It is a bronchoscopic procedure in which radiofrequency energy is applied to the airway wall, resulting in decreased airway smooth muscle burden. Human trials have shown that bronchial thermoplasty may reduce asthma exacerbations and improve quality of life in patients with severe uncontrolled asthma. It has been demonstrated to be a safe procedure, with most adverse events being early and mild. More studies are required to understand the precise effects of bronchial thermoplasty on the asthmatic airway and optimal parameters to appropriately select patients for this novel procedure.
KW - Airway smooth muscle
KW - Bronchial thermoplasty
KW - Radiofrequency ablation
KW - Severe asthma
UR - http://www.scopus.com/inward/record.url?scp=85060433074&partnerID=8YFLogxK
U2 - 10.1016/j.ccm.2018.10.015
DO - 10.1016/j.ccm.2018.10.015
M3 - Review article
C2 - 30691712
AN - SCOPUS:85060433074
SN - 0272-5231
VL - 40
SP - 193
EP - 207
JO - Clinics in Chest Medicine
JF - Clinics in Chest Medicine
IS - 1
ER -