@article{93dfb281bef442d6977493ee5cbb15c3,
title = "Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype",
abstract = "Recent epidemics of Zika virus (ZIKV) have been associated with congenital malformation during pregnancy and Guillain-Barr{\'e} syndrome. There are two ZIKV lineages (African and Asian) that share >95% amino acid identity. Little is known regarding the ability of neutralizing antibodies elicited against one lineage to protect against the other. We investigated the breadth of the neutralizing antibody response following ZIKV infection by measuring the sensitivity of six ZIKV strains to neutralization by ZIKV-confirmed convalescent human serum or plasma samples. Contemporary Asian and early African ZIKV strains were similarly sensitive to neutralization regardless of the cellular source of virus. Furthermore, mouse immune serum generated after infection with African or Asian ZIKV strains was capable of neutralizing homologous and heterologous ZIKV strains equivalently. Because our study only defines a single ZIKV serotype, vaccine candidates eliciting robust neutralizing antibody responses should inhibit infection of both ZIKV lineages, including strains circulating in the Americas.",
author = "Dowd, {Kimberly A.} and DeMaso, {Christina R.} and Pelc, {Rebecca S.} and Speer, {Scott D.} and Smith, {Alexander R.Y.} and Leslie Goo and Platt, {Derek J.} and Mascola, {John R.} and Graham, {Barney S.} and Mulligan, {Mark J.} and Diamond, {Michael S.} and Ledgerwood, {Julie E.} and Pierson, {Theodore C.}",
note = "Funding Information: This work was funded by the intramural program of the National Institute of Allergy and Infectious Disease to the Division of Intramural Research and the Vaccine Research Center and extramural grant R01AI073755 to M.S.D. M.J.M. was supported by funds from the Emory University School of Medicine and the Georgia Research Alliance. We thank X. de Lamballerie (Emergence des Pathologies Virales, Aix-Marseille Universit{\'e}) and the European Virus Archive Goes Global (EVAg) for providing the H/PF/2013 ZIKV strain and Stephen S. Whitehead (NIAID) for the Brazil Paraiba/2015 virus. We are grateful to the subjects for providing research samples and to Ingelise Gordon (VRC), Pamela Costner (VRC), Adam Dezure (VRC), Lilin Lai (Emory), Natalie Thornburg (Emory), Henry Wu (Emory), Srilatha Edupuganti (Emory), Allison Beck, (Emory), Sree Aramgam (Emory), and Pamela Lankford-Turner (Emory) for assistance with ZIKV patients and the collection of samples. We also thank Amanda Feldpausch (Georgia Department of Health), Jennifer Govero (Washington University), and Estefania Fernandez (Washington University) for their help with these studies. M.S.D. is a consultant for Inbios, Visterra, Sanofi, and Takeda Pharmaceuticals, is on the Scientific Advisory Boards of Moderna and OraGene, and is a recipient of research grants from Moderna, Sanofi, and Visterra. Publisher Copyright: {\textcopyright} 2016",
year = "2016",
month = aug,
day = "9",
doi = "10.1016/j.celrep.2016.07.049",
language = "English",
volume = "16",
pages = "1485--1491",
journal = "Cell Reports",
issn = "2211-1247",
number = "6",
}