TY - JOUR
T1 - Brief research report
T2 - Repurposing pentoxifylline to treat intense acute swimming–Induced delayed-onset muscle soreness in mice: Targeting peripheral and spinal cord nociceptive mechanisms
AU - Borghi, Sergio M.
AU - Zaninelli, Tiago H.
AU - Saraiva-Santos, Telma
AU - Bertozzi, Mariana M.
AU - Cardoso, Renato D.R.
AU - Carvalho, Thacyana T.
AU - Ferraz, Camila R.
AU - Camilios-Neto, Doumit
AU - Cunha, Fernando Q.
AU - Cunha, Thiago M.
AU - Pinho-Ribeiro, Felipe A.
AU - Casagrande, Rubia
AU - Verri, Waldiceu A.
N1 - Funding Information:
This work was supported under Brazilian grants from CAPES (finance code 001), CNPq (#309633/2021-4; #307852/2019-9; #405027/2021-4; #427946/2018-2; #307689/2022-0), FAPESP (#2013/08216-2; Center for Research in Inflammatory Disease), PRONEX grant supported by Araucária Foundation, SETI, MCTI, CNPq, and Paraná State Government (#014/2017).
Publisher Copyright:
Copyright © 2023 Borghi, Zaninelli, Saraiva-Santos, Bertozzi, Cardoso, Carvalho, Ferraz, Camilios-Neto, Cunha, Cunha, Pinho-Ribeiro, Casagrande and Verri.
PY - 2023/1/10
Y1 - 2023/1/10
N2 - In this study, we pursue determining the effect of pentoxifylline (Ptx) in delayed-onset muscle soreness (DOMS) triggered by exposing untrained mice to intense acute swimming exercise (120 min), which, to our knowledge, has not been investigated. Ptx treatment (1.5, 4.5, and 13.5 mg/kg; i.p., 30 min before and 12 h after the session) reduced intense acute swimming–induced mechanical hyperalgesia in a dose-dependent manner. The selected dose of Ptx (4.5 mg/kg) inhibited recruitment of neutrophils to the muscle tissue, oxidative stress, and both pro- and anti-inflammatory cytokine production in the soleus muscle and spinal cord. Furthermore, Ptx treatment also reduced spinal cord glial cell activation. In conclusion, Ptx reduces pain by targeting peripheral and spinal cord mechanisms of DOMS.
AB - In this study, we pursue determining the effect of pentoxifylline (Ptx) in delayed-onset muscle soreness (DOMS) triggered by exposing untrained mice to intense acute swimming exercise (120 min), which, to our knowledge, has not been investigated. Ptx treatment (1.5, 4.5, and 13.5 mg/kg; i.p., 30 min before and 12 h after the session) reduced intense acute swimming–induced mechanical hyperalgesia in a dose-dependent manner. The selected dose of Ptx (4.5 mg/kg) inhibited recruitment of neutrophils to the muscle tissue, oxidative stress, and both pro- and anti-inflammatory cytokine production in the soleus muscle and spinal cord. Furthermore, Ptx treatment also reduced spinal cord glial cell activation. In conclusion, Ptx reduces pain by targeting peripheral and spinal cord mechanisms of DOMS.
KW - cytokine
KW - glial cells
KW - muscle mechanical hyperalgesia
KW - oxidative stress
KW - pentoxifylline
UR - http://www.scopus.com/inward/record.url?scp=85146773998&partnerID=8YFLogxK
U2 - 10.3389/fphar.2022.950314
DO - 10.3389/fphar.2022.950314
M3 - Article
C2 - 36703752
AN - SCOPUS:85146773998
SN - 1663-9812
VL - 13
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 950314
ER -