TY - JOUR
T1 - Bridging the gap between preclinical scientists, clinical researchers, and clinicians
T2 - From animal research to clinical practice
AU - Begasse de Dhaem, Olivia
AU - Wattiez, Anne Sophie
AU - de Boer, Irene
AU - Pavitt, Sara
AU - Powers, Scott W.
AU - Pradhan, Amynah
AU - Gelfand, Amy A.
AU - Nahman-Averbuch, Hadas
N1 - Funding Information:
serves as an Executive Editor for the journal and as a consultant for Neurolytic Healthcare. reports no conflicts of interest. reports independent research support from the International Retinal Research Foundation (IRRF) and the Dutch Heart Foundation. serves on the Theranica advisory board. reports scientific consultation: Theranica, Biohaven; grants to Cincinnati Children's from National Institutes of Health; Associate Editor, ; member, Board of Directors, American Headache Society. has a research contract with Lundbeck. In the last 24 months, has received honoraria from UpToDate (for authorship), and stipends from for editorial work (last in July 2020) and from the American Headache Society for her role as Editor of . She received grant support from the Duke Clinical Research Institute and the UCSF Resource Allocation Program. is on the Editorial Board of , and is a member of the Board of Directors of USASP. Olivia Begasse de Dhaem Pain Medicine Anne‐Sophie Wattiez I. de Boer Sara Pavitt Scott Powers Headache Amynah Pradhan Amy Gelfand JAMA Neurology Headache Hadas Nahman‐Averbuch Pain Reports
Publisher Copyright:
© 2023 American Headache Society.
PY - 2023/1
Y1 - 2023/1
N2 - Background: Collaborations amongst researchers and clinicians with complementary areas of expertise enhance knowledge for everyone and can lead to new discoveries. To facilitate these interactions, shared language and a general understanding of how colleagues in different subfields of headache and headache research approach their work are needed. Methods: This narrative review focuses on research methods applied in animal studies, human studies including clinical trials, and provides an overview of clinical practice. Results: For animal studies, we describe concepts needed to evaluate the quality and relevance of preclinical studies. For human research, fundamental concepts of neuroimaging, quantitative sensory testing, genetic and epidemiological research methods, and clinical research methodology that are commonly used in headache research are summarized. In addition, we provide an understanding of what guides headache clinicians, and summarize the practical approach to migraine management in adults and children. Conclusions: It is hoped that this review facilitates further dialogue between clinicians and researchers that will help guide future research efforts and implementation of research findings into clinical practice.
AB - Background: Collaborations amongst researchers and clinicians with complementary areas of expertise enhance knowledge for everyone and can lead to new discoveries. To facilitate these interactions, shared language and a general understanding of how colleagues in different subfields of headache and headache research approach their work are needed. Methods: This narrative review focuses on research methods applied in animal studies, human studies including clinical trials, and provides an overview of clinical practice. Results: For animal studies, we describe concepts needed to evaluate the quality and relevance of preclinical studies. For human research, fundamental concepts of neuroimaging, quantitative sensory testing, genetic and epidemiological research methods, and clinical research methodology that are commonly used in headache research are summarized. In addition, we provide an understanding of what guides headache clinicians, and summarize the practical approach to migraine management in adults and children. Conclusions: It is hoped that this review facilitates further dialogue between clinicians and researchers that will help guide future research efforts and implementation of research findings into clinical practice.
KW - animal models
KW - clinical practice
KW - clinical trials
KW - genetic methods
KW - neuroimaging methods
KW - quantitative sensory testing
UR - http://www.scopus.com/inward/record.url?scp=85146298564&partnerID=8YFLogxK
U2 - 10.1111/head.14441
DO - 10.1111/head.14441
M3 - Review article
C2 - 36633108
AN - SCOPUS:85146298564
SN - 0017-8748
VL - 63
SP - 25
EP - 39
JO - Headache
JF - Headache
IS - 1
ER -