Breast neuroendocrine neoplasms: practical applications and continuing challenges in the era of the 5th edition of the WHO classification of breast tumours

Gregory R. Bean, Chieh Yu Lin

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

The classification and nomenclature for breast neuroendocrine neoplasms have undergone several iterations. The most recent (5th) edition of the World Health Organization (WHO) classification of breast tumours defines pure primary neuroendocrine neoplasms into neuroendocrine tumour (NET) and neuroendocrine carcinoma (NEC), in alignment with other organ systems, and segregates other lesions that exhibit neuroendocrine morphology/markers into alternative categories. This review will provide an update of the nomenclature evolution, diagnostic criteria and ancillary studies, and prognostic and clinical management of breast neuroendocrine neoplasia, focusing on a practical approach and highlighting remaining issues in this field.

Original languageEnglish
Pages (from-to)139-147
Number of pages9
JournalDiagnostic Histopathology
Volume27
Issue number4
DOIs
StatePublished - Apr 2021

Keywords

  • breast
  • large cell neuroendocrine carcinoma
  • neuroendocrine neoplasm
  • neuroendocrine tumour
  • small cell neuroendocrine carcinoma

Fingerprint

Dive into the research topics of 'Breast neuroendocrine neoplasms: practical applications and continuing challenges in the era of the 5th edition of the WHO classification of breast tumours'. Together they form a unique fingerprint.

Cite this