TY - JOUR
T1 - Breast neuroendocrine neoplasms
T2 - practical applications and continuing challenges in the era of the 5th edition of the WHO classification of breast tumours
AU - Bean, Gregory R.
AU - Lin, Chieh Yu
N1 - Publisher Copyright:
© 2021
PY - 2021/4
Y1 - 2021/4
N2 - The classification and nomenclature for breast neuroendocrine neoplasms have undergone several iterations. The most recent (5th) edition of the World Health Organization (WHO) classification of breast tumours defines pure primary neuroendocrine neoplasms into neuroendocrine tumour (NET) and neuroendocrine carcinoma (NEC), in alignment with other organ systems, and segregates other lesions that exhibit neuroendocrine morphology/markers into alternative categories. This review will provide an update of the nomenclature evolution, diagnostic criteria and ancillary studies, and prognostic and clinical management of breast neuroendocrine neoplasia, focusing on a practical approach and highlighting remaining issues in this field.
AB - The classification and nomenclature for breast neuroendocrine neoplasms have undergone several iterations. The most recent (5th) edition of the World Health Organization (WHO) classification of breast tumours defines pure primary neuroendocrine neoplasms into neuroendocrine tumour (NET) and neuroendocrine carcinoma (NEC), in alignment with other organ systems, and segregates other lesions that exhibit neuroendocrine morphology/markers into alternative categories. This review will provide an update of the nomenclature evolution, diagnostic criteria and ancillary studies, and prognostic and clinical management of breast neuroendocrine neoplasia, focusing on a practical approach and highlighting remaining issues in this field.
KW - breast
KW - large cell neuroendocrine carcinoma
KW - neuroendocrine neoplasm
KW - neuroendocrine tumour
KW - small cell neuroendocrine carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85100047372&partnerID=8YFLogxK
U2 - 10.1016/j.mpdhp.2021.01.001
DO - 10.1016/j.mpdhp.2021.01.001
M3 - Review article
AN - SCOPUS:85100047372
SN - 1756-2317
VL - 27
SP - 139
EP - 147
JO - Diagnostic Histopathology
JF - Diagnostic Histopathology
IS - 4
ER -