Breast conserving surgery and definitive irradiation for early stage breast cancer

Dennis E. Hallahan, Arthur G. Michel, Howard J. Halpern, Azhar M. Awan, Richard Desser, Jacob Bitran, Wendy Recant, Brenda Wyman, Danny R. Spelbring, Ralph R. Weichselbaum

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23 Scopus citations


Breast conserving surgery and postoperative breast radiotherapy were used to treat 219 cases of AJCC Stage I and II breast carcinoma at the Michael Reese and University of Chicago Hospitals. Most patients were treated with lumpectomy and axillary sampling followed by breast irradiation to a dose of 46 Gy followed by a boost dose of 14-16 Gy to the surgical bed. The 5-year actuarial local control is 92%. Follow-up is 1 to 10 years and the median follow-up is 36 months. Of the seven patients who recurred in the breast, three failed in the boost site and three failed adjacent to the boost site. The seventh patient recurred diffusely in the breast and skin. Four of the seven recurrences were in patients with positive surgical margins. The 5-year actuarial relapse-free survival is 80%. Factors which had an adverse affect on the cosmetic results were a scar length greater than 8 cm and a volume of resected breast tissue greater than 100 cm3 Treatment related complications were minor and infrequent. Breast conserving surgery followed by radiation therapy is effective in achieving local control with good to excellent cosmetic results.

Original languageEnglish
Pages (from-to)1211-1216
Number of pages6
JournalInternational journal of radiation oncology, biology, physics
Issue number6
StatePublished - Dec 1989


  • Breast cancer
  • Conservative surgery
  • Cosmetic results
  • Patterns of failure
  • Radiotherapy


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