TY - JOUR
T1 - Breast cancer susceptibility loci and mammographic density
AU - Tamimi, Rulla M.
AU - Cox, David
AU - Kraft, Peter
AU - Colditz, Graham A.
AU - Hankinson, Susan E.
AU - Hunter, David J.
N1 - Funding Information:
We are grateful to the participants of the Nurses' Health Study for their outstanding dedication and commitment to the study. This work was supported by Public Health Service Grants CA087969, CA75016 and SPORE in Breast Cancer CA089393 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services. Dr Graham Colditz is supported in part by an American Cancer Society Cissy Hornung Clinical Research Professorship. The study sponsors had no role in the design of the study; the collection, analysis and interpretation of the data; the writing of the manuscript; or the decision to submit the manuscript for publication.
PY - 2008/8/5
Y1 - 2008/8/5
N2 - Introduction: Recently, the Breast Cancer Association Consortium (BCAC) conducted a multi-stage genome-wide association study and identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer risk. Given the high degree of heritability of mammographic density and its strong association with breast cancer, it was hypothesised that breast cancer susceptibility loci may also be associated with breast density and provide insight into the biology of breast density and how it influences breast cancer risk.Methods: We conducted an analysis in the Nurses' Health Study (n = 1121) to assess the relation between 11 breast cancer susceptibility loci and mammographic density. At the time of their mammogram, 217 women were premenopausal and 904 women were postmenopausal. We used generalised linear models adjusted for covariates to determine the mean percentage of breast density according to genotype.Results: Overall, no association between the 11 breast cancer susceptibility loci and mammographic density was seen. Among the premenopausal women, three SNPs (rs12443621 [TNRc9/LOC643714], rs3817198 [lymphocyte-specific protein-1] and rs4666451) were marginally associated with mammographic density (p < 0.10). All three of these SNPs showed an association that was consistent with the direction in which these alleles influence breast cancer risk. The difference in mean percentage mammographic density comparing homozygous wildtypes to homozygous variants ranged from 6.3 to 8.0%. None of the 11 breast cancer loci were associated with postmenopausal breast density.Conclusion: Overall, breast cancer susceptibility loci identified through a genome-wide association study do not appear to be associated with breast cancer risk.
AB - Introduction: Recently, the Breast Cancer Association Consortium (BCAC) conducted a multi-stage genome-wide association study and identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer risk. Given the high degree of heritability of mammographic density and its strong association with breast cancer, it was hypothesised that breast cancer susceptibility loci may also be associated with breast density and provide insight into the biology of breast density and how it influences breast cancer risk.Methods: We conducted an analysis in the Nurses' Health Study (n = 1121) to assess the relation between 11 breast cancer susceptibility loci and mammographic density. At the time of their mammogram, 217 women were premenopausal and 904 women were postmenopausal. We used generalised linear models adjusted for covariates to determine the mean percentage of breast density according to genotype.Results: Overall, no association between the 11 breast cancer susceptibility loci and mammographic density was seen. Among the premenopausal women, three SNPs (rs12443621 [TNRc9/LOC643714], rs3817198 [lymphocyte-specific protein-1] and rs4666451) were marginally associated with mammographic density (p < 0.10). All three of these SNPs showed an association that was consistent with the direction in which these alleles influence breast cancer risk. The difference in mean percentage mammographic density comparing homozygous wildtypes to homozygous variants ranged from 6.3 to 8.0%. None of the 11 breast cancer loci were associated with postmenopausal breast density.Conclusion: Overall, breast cancer susceptibility loci identified through a genome-wide association study do not appear to be associated with breast cancer risk.
UR - https://www.scopus.com/pages/publications/65849089160
U2 - 10.1186/bcr2127
DO - 10.1186/bcr2127
M3 - Article
C2 - 18681954
AN - SCOPUS:65849089160
SN - 1465-5411
VL - 10
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 4
M1 - R66
ER -