TY - JOUR
T1 - Breast cancer stem cells
T2 - Are we ready to go from bench to bedside?
AU - Lin, Chieh Yu
AU - Barry-Holson, Keegan Q.
AU - Allison, Kimberly H.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Since the discovery of breast cancer stem cells (BCSCs) more than 10 years ago, a body of exciting research has developed. The intrinsic properties of BCSCs, including self-renewal and the ability to give rise to heterogeneous progeny, make BCSCs a likely source of tumour initiation, heterogeneity, progression and metastasis. BCSCs are also inherently resistant to conventional therapies and are therefore thought to contribute to disease recurrence. In this review, we will focus on both the challenges and recent advances in the characterization of BCSCs with respect to phenotype, molecular signature and their role in the behaviour of the different molecular subtypes of breast cancer. Of most importance is our ability to translate our growing knowledge base into the development of targeted therapies with the goal of reducing adverse outcomes in breast cancer patients.
AB - Since the discovery of breast cancer stem cells (BCSCs) more than 10 years ago, a body of exciting research has developed. The intrinsic properties of BCSCs, including self-renewal and the ability to give rise to heterogeneous progeny, make BCSCs a likely source of tumour initiation, heterogeneity, progression and metastasis. BCSCs are also inherently resistant to conventional therapies and are therefore thought to contribute to disease recurrence. In this review, we will focus on both the challenges and recent advances in the characterization of BCSCs with respect to phenotype, molecular signature and their role in the behaviour of the different molecular subtypes of breast cancer. Of most importance is our ability to translate our growing knowledge base into the development of targeted therapies with the goal of reducing adverse outcomes in breast cancer patients.
KW - Breast cancer stem cells
KW - Cancer stem cells
KW - Stem cell therapy
UR - http://www.scopus.com/inward/record.url?scp=84954531311&partnerID=8YFLogxK
U2 - 10.1111/his.12868
DO - 10.1111/his.12868
M3 - Review article
C2 - 26768034
AN - SCOPUS:84954531311
SN - 0309-0167
VL - 68
SP - 119
EP - 137
JO - Histopathology
JF - Histopathology
IS - 1
ER -